Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4
CCL5
CD4+ T cells
CXCL10
CXCL9
Chemokines
Neutrophils
Sleep deprivation
Journal
Sleep & breathing = Schlaf & Atmung
ISSN: 1522-1709
Titre abrégé: Sleep Breath
Pays: Germany
ID NLM: 9804161
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
13
01
2019
accepted:
16
04
2019
revised:
02
04
2019
pubmed:
2
5
2019
medline:
14
1
2021
entrez:
2
5
2019
Statut:
ppublish
Résumé
The state of knowledge about the effect of sleep deprivation on the immune system is scarce and conflicting. It would therefore be useful to investigate the consequences of sleep deprivation on the immune system. We have studied the effect of sleep deprivation on the changes in neutrophil functions, and the ex vivo proliferative pattern of CD4 Healthy volunteers were followed for 3 weeks. They had normal sleep in weeks 1 and 3 and they were sleep-deprived on week 2, sleeping < 6 h per 24 h, a pattern similar to sleep behaviors of many chronically sleep-deprived individuals. We assessed the levels of Th1/Th2 and inflammatory cytokines and chemokines, CD4 Our results suggest that sleep deprivation leads to a decreased neutrophil capacity to phagocytose bacteria and activate NADPH oxidase (p < 0.05). Sleep deprivation was associated with a potential increase in CXCL9 levels and decrease in CXCL10/CXCL9 and CCL5/CXCL9 ratios (p < 0.05). Furthermore, our results suggest that the decrease in CD4 Sleep deprivation may lead to a decreased phagocytosis and NADPH oxidase activity in neutrophils and a decrease in the levels of CD4
Identifiants
pubmed: 31041780
doi: 10.1007/s11325-019-01851-1
pii: 10.1007/s11325-019-01851-1
doi:
Substances chimiques
Chemokines
0
Cytokines
0
NADPH Oxidases
EC 1.6.3.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1331-1339Subventions
Organisme : This study was supported by the College of Medicine and Health Sciences, Sultan Qaboos University
ID : IG/MED/ANAT/13/01
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