Novel
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 05 2019
23 05 2019
Historique:
pubmed:
3
5
2019
medline:
2
6
2020
entrez:
3
5
2019
Statut:
ppublish
Résumé
Myelin is the protective sheath that surrounds nerves in vertebrates to protect axons, which thereby facilitates impulse conduction. Damage to myelin is associated with many neurodegenerative diseases such as multiple sclerosis and also includes spinal cord injury (SCI). The small size of the spinal cord poses formidable challenges to in vivo monitoring of myelination, which we investigated via conducting a structure-activity relationship study to determine the optimum positron-emitting agent to use for imaging myelin using positron emission tomography (PET). From these studies, [
Identifiants
pubmed: 31042384
doi: 10.1021/acs.jmedchem.8b01354
doi:
Substances chimiques
Fluorine Radioisotopes
0
Ligands
0
Small Molecule Libraries
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4902-4914Subventions
Organisme : NINDS NIH HHS
ID : R21 NS111433
Pays : United States