Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism.
Animals
Brain Stem
/ metabolism
Disease Models, Animal
Dopamine
/ metabolism
Dopaminergic Neurons
/ metabolism
Gastrointestinal Motility
Male
Neural Inhibition
Neuronal Plasticity
Paraquat
Parkinsonian Disorders
/ chemically induced
Rats, Sprague-Dawley
Receptors, Dopamine D1
/ metabolism
Receptors, Dopamine D2
/ metabolism
Stomach
/ innervation
Vagus Nerve
/ metabolism
brain stem
dorsal motor nucleus of the vagus
in vivo vagus
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
pubmed:
3
5
2019
medline:
19
2
2020
entrez:
3
5
2019
Statut:
ppublish
Résumé
The majority of patients with Parkinson's disease (PD) experience gastrointestinal dysfunction. Recently, we described a nigro-vagal pathway that uses dopaminergic (DA) inputs to the dorsal motor nucleus of the vagus (DMV) and A2 area neurons to modulate gastric motility and tone. This pathway is disrupted in a rodent model of PD. The aim of the present study was to test the hypothesis that brain-stem DA modulation of gastric tone and motility is altered in a rodent model of PD. Male Sprague-Dawley rats received three weekly intraperitoneal injections of paraquat (10 mg/kg) or saline (control). In naive conditions, microinjection of DA into the DMV induced a gastroinhibitory response in 100% of animals. In 19 of 28 PQ-treated animals, however, microinjection of DA into the DVC induced a biphasic response, with an initial increase in gastric tone and motility followed by a profound gastroinhibition. The excitatory response to DA microinjection was attenuated by a combination of DA type 1 (DA1)- and DA2-like receptor antagonists. Conversely, the inhibitory response was reduced by the DA2-like receptor antagonist only. Pretreatment with the α
Identifiants
pubmed: 31042398
doi: 10.1152/ajpgi.00076.2019
pmc: PMC6689734
doi:
Substances chimiques
DRD2 protein, rat
0
Receptors, Dopamine D1
0
Receptors, Dopamine D2
0
dopamine D1A receptor
0
Paraquat
PLG39H7695
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
G1-G7Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK055530
Pays : United States
Références
J Comp Neurol. 1994 Jun 1;344(1):121-36
pubmed: 7914895
Auton Neurosci. 2013 Jun;176(1-2):48-53
pubmed: 23403122
J Neurol Sci. 2010 Feb 15;289(1-2):69-73
pubmed: 19717168
Acta Neuropathol. 2008 Apr;115(4):461-70
pubmed: 18297291
Nat Rev Neurol. 2016 Mar;12(3):150-60
pubmed: 26868680
Prog Brain Res. 2010;184:17-33
pubmed: 20887868
Nat Rev Neurol. 2013 Jan;9(1):13-24
pubmed: 23183883
J Comp Neurol. 1985 Mar 15;233(3):308-32
pubmed: 2858497
Nat Rev Neurosci. 2017 Mar 17;18(4):251-259
pubmed: 28303016
Eur J Neurol. 2008 Apr;15 Suppl 1:14-20
pubmed: 18353132
Neurogastroenterol Motil. 2016 Dec;28(12):1781-1791
pubmed: 27611012
Nat Rev Neurosci. 2017 Aug;18(8):509
pubmed: 28720825
Neuropathol Appl Neurobiol. 2002 Aug;28(4):283-91
pubmed: 12175340
Trends Neurosci. 2006 Apr;29(4):192-9
pubmed: 16519953
J Neurol. 2013 May;260(5):1332-8
pubmed: 23263478
Compr Physiol. 2014 Oct;4(4):1339-68
pubmed: 25428846
Neurobiol Dis. 2012 Jun;46(3):559-64
pubmed: 22048068
J Neurosci. 2011 Sep 28;31(39):14024-31
pubmed: 21957263
Brain Res. 2011 Oct 28;1420:59-67
pubmed: 21955729
Neuroscience. 1997 Apr;77(4):1077-89
pubmed: 9130789
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1002-8
pubmed: 17170022
Nat Rev Gastroenterol Hepatol. 2016 Jul;13(7):389-401
pubmed: 27251213
Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R711-20
pubmed: 24990858
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G434-G441
pubmed: 28729246
Parkinsonism Relat Disord. 2015 Dec;21(12):1407-14
pubmed: 26499757
Ann Neurol. 2010 Nov;68(5):619-28
pubmed: 20882603
Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G1013-23
pubmed: 25277799
Neurogastroenterol Motil. 2008 Jul;20(7):741-9
pubmed: 18557892
Neurogastroenterol Motil. 2019 Apr;31(4):e13546
pubmed: 30740834
Lancet Neurol. 2015 Jun;14(6):625-39
pubmed: 25987282
Brain Res. 2018 Aug 15;1693(Pt B):201-206
pubmed: 29360467
Nat Rev Neurosci. 2006 Nov;7(11):873-81
pubmed: 17053811
Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S30-S33
pubmed: 28780180
Int J Environ Res Public Health. 2016 Sep 03;13(9):
pubmed: 27598189
J Hand Ther. 2009 Apr-Jun;22(2):109-13; quiz 114
pubmed: 19216051
Synapse. 1996 Nov;24(3):224-32
pubmed: 8923662
NPJ Parkinsons Dis. 2018 Sep 27;4:30
pubmed: 30302391
Curr Aging Sci. 2011 Feb;4(1):19-24
pubmed: 21204780
Neurobiol Dis. 2012 Jun;46(3):597-606
pubmed: 22236386
Gastroenterology. 2017 Dec;153(6):1581-1593
pubmed: 28912019