Distinct Requirements of CHD4 during B Cell Development and Antibody Response.

Animals B-Lymphocytes / cytology Cell Differentiation Cell Proliferation Cells, Cultured Chromatin Assembly and Disassembly DNA Helicases / genetics Genes, Immunoglobulin Heavy Chain Immunoglobulin Class Switching Mice Tumor Suppressor Protein p53 / genetics
AID CHD4 H3K9me3 NuRD complex chromatin remodeling class switch recombination germinal centers p53

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
30 04 2019
Historique:
received: 30 11 2018
revised: 15 03 2019
accepted: 01 04 2019
entrez: 3 5 2019
pubmed: 3 5 2019
medline: 7 7 2020
Statut: ppublish

Résumé

The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remodeling NuRD complex, directly binds H3K9me3, an epigenetic mark present at the Igh locus during CSR. We find that CHD4 is essential for early B cell development but is dispensable for the homeostatic maintenance of mature, naive B cells. However, loss of CHD4 in mature B cells impairs CSR because of suboptimal targeting of AID to the Igh locus. Additionally, we find that CHD4 represses p53 expression to promote B cell proliferation. This work reveals distinct roles for CHD4 in B cell development and CSR and links the H3K9me3 epigenetic mark with AID recruitment to the Igh locus.

Identifiants

DOI: 10.1016/j.celrep.2019.04.011 PMID: 31042474 PMC: PMC6527137
pubmed: 31042474
pii: S2211-1247(19)30466-8
doi: 10.1016/j.celrep.2019.04.011
pmc: PMC6527137
mid: NIHMS1528295
pii:
doi:

Substances chimiques

TP53 protein, human 0
Tumor Suppressor Protein p53 0
Mi-2beta protein, mouse EC 3.6.1.3
DNA Helicases EC 3.6.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1472-1486.e5

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI100874
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI072194
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA185660
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009149
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124186
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI034206
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI137752
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130043
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI072194
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Wei-Feng Yen (WF)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA.

Rahul Sharma (R)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Montserrat Cols (M)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Colleen M Lau (CM)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Ashutosh Chaudhry (A)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Priyanka Chowdhury (P)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

William T Yewdell (WT)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Bharat Vaidyanathan (B)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Amy Sun (A)

Department of Pathology, New York University School of Medicine, New York, NY, USA.

Maryaline Coffre (M)

Department of Pathology, New York University School of Medicine, New York, NY, USA.

Joseph N Pucella (JN)

Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA.

Chun-Chin Chen (CC)

Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Maria Jasin (M)

Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Joseph C Sun (JC)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA.

Alexander Y Rudensky (AY)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Sergei B Koralov (SB)

Department of Pathology, New York University School of Medicine, New York, NY, USA.

Jayanta Chaudhuri (J)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA. Electronic address: chaudhuj@mskcc.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Cellules › Cellules cultivées › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Helicase › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes de chaine lourde d'immunoglobuline › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Réarrangement des gènes des lymphocytes B › Réarrangement des gènes des chaines lourdes des lymphocytes B › Commutation de classe des immunoglobulines › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Distinct Requirements of CHD4 during B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Distinct Requirements of CHD4 during B Cell...