H3.3 Barcoding of Nucleus Accumbens Transcriptional Activity Identifies Novel Molecular Cascades Associated with Cocaine Self-administration in Mice.
ChIP-seq
EGR1
RBPJ1
RNA-seq
SOX4
histone
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
03 07 2019
03 07 2019
Historique:
received:
03
01
2019
revised:
17
04
2019
accepted:
26
04
2019
pubmed:
3
5
2019
medline:
17
6
2020
entrez:
3
5
2019
Statut:
ppublish
Résumé
Although numerous epigenetic modifications have been associated with addiction, little work has explored the turnover of histone variants. Uniquely, the H3.3 variant incorporates stably and preferentially into chromatin independently of DNA replication at active sites of transcription and transcription factor binding. Thus, genomic regions associated with H3.3-containing nucleosomes are particularly likely to be involved in plasticity, such as following repeated cocaine exposure. A recently developed mouse line expressing a neuron-specific hemagglutinin (HA)-tagged H3.3 protein was used to track transcriptionally active sites cumulatively across 19 d of cocaine self-administration. RNA-seq and H3.3-HA ChIP-seq analyses were performed on NAcc tissue collected following cocaine or food self-administration in male mice. RNA sequencing revealed five genes upregulated in cocaine relative to food self-administering mice:
Identifiants
pubmed: 31043484
pii: JNEUROSCI.0015-19.2019
doi: 10.1523/JNEUROSCI.0015-19.2019
pmc: PMC6607753
doi:
Substances chimiques
Histones
0
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5247-5254Subventions
Organisme : NIMH NIH HHS
ID : R21 MH102679
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA039308
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033641
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH087463
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA028874
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA040837
Pays : United States
Informations de copyright
Copyright © 2019 the authors.
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