Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Animals
Arteries
/ pathology
Atherosclerosis
/ pathology
Cell Death
Cell Membrane
/ drug effects
Disease Models, Animal
Female
Histones
/ antagonists & inhibitors
Inflammation
/ metabolism
Mice
Mice, Inbred C57BL
Myocytes, Smooth Muscle
/ pathology
Neutrophils
/ cytology
Porosity
Protein Binding
/ drug effects
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
28
11
2017
accepted:
02
04
2019
pubmed:
3
5
2019
medline:
18
12
2019
entrez:
3
5
2019
Statut:
ppublish
Résumé
The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by non-programmed cell death
Identifiants
pubmed: 31043745
doi: 10.1038/s41586-019-1167-6
pii: 10.1038/s41586-019-1167-6
pmc: PMC6716525
mid: NIHMS1046629
doi:
Substances chimiques
Histones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
236-240Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM008042
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI125429
Pays : United States
Organisme : NIH HHS
ID : R56AI125429-01A1
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008185
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR071307
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
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