Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis.

Animals Ascomycota / chemistry Crystallography, X-Ray Endophytes / chemistry Magnetic Resonance Spectroscopy Mice Sesquiterpenes / chemistry

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
24 05 2019
Historique:
pubmed: 3 5 2019
medline: 29 8 2020
entrez: 3 5 2019
Statut: ppublish

Résumé

Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC

Identifiants

DOI: 10.1021/acs.jnatprod.8b00938 PMID: 31044595
pubmed: 31044595
doi: 10.1021/acs.jnatprod.8b00938
doi:

Substances chimiques

Sesquiterpenes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1055-1062

Auteurs

Shuai Liu (S)

Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
Faculty of Life Science and Food Engineering , Huaiyin Institute of Technology , Huaian 223003 , People's Republic of China.

Yuping Zhao (Y)

Faculty of Life Science and Food Engineering , Huaiyin Institute of Technology , Huaian 223003 , People's Republic of China.

Christian Heering (C)

Institute of Inorganic and Structural Chemistry , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.

Christoph Janiak (C)

Institute of Inorganic and Structural Chemistry , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
ORCID: 0000-0002-6288-9605

Werner E G Müller (WEG)

Institute of Physiological Chemistry , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , 55128 Mainz , Germany.

Sergi Hervé Akoné (SH)

Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
Department of Chemistry, Faculty of Science , University of Douala , PO Box 24157, Douala , Cameroon.

Zhen Liu (Z)

Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
ORCID: 0000-0003-3314-7853

Peter Proksch (P)

Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Stades d'organismes › Endophytes › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sesquiterpenoids from the Endophytic Fungus...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Sesquiterpenoids from the Endophytic Fungus...