Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review.
HFpEF
HFrEF
aging
cardiorespiratory fitness
comorbidities
exercise capacity
exercise intolerance
exercise training
fatigue
heart failure
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
07 05 2019
07 05 2019
Historique:
received:
21
01
2019
accepted:
21
01
2019
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
4
3
2020
Statut:
ppublish
Résumé
Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and increased mortality. While impaired cardiac reserve is considered to be central in HF, reduced exercise and functional capacity are the result of key patient characteristics and multisystem dysfunction, including aging, impaired pulmonary reserve, as well as peripheral and respiratory skeletal muscle dysfunction. We herein review the different modalities to quantify exercise intolerance, the pathophysiology of HF, and comorbid conditions as they lead to reductions in exercise and functional capacity, highlighting the fact that distinct causes may coexist and variably contribute to exercise intolerance in patients with HF.
Identifiants
pubmed: 31047010
pii: S0735-1097(19)33923-3
doi: 10.1016/j.jacc.2019.01.072
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2209-2225Informations de copyright
Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.