Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
3-Hydroxybutyric Acid
/ blood
3T3-L1 Cells
Adiponectin
/ blood
Adipose Tissue
/ metabolism
Animals
Blotting, Western
Cells, Cultured
Fatty Acids
/ blood
Glycerol
/ blood
Humans
Immunohistochemistry
Insulin
/ blood
Intestinal Absorption
/ genetics
Lipid Metabolism
/ genetics
Lipolysis
/ genetics
Liver
/ enzymology
Mice
Mice, Inbred C57BL
Monoacylglycerol Lipases
/ deficiency
Obesity
/ genetics
Oxidation-Reduction
Peroxisome Proliferator-Activated Receptors
/ metabolism
Triglycerides
/ blood
adipocyte
adipocytes/obesity
fatty acid/metabolism
lipolysis and fatty acid metabolism
monoacylglycerol lipase
nonalcoholic fatty liver disease
nuclear receptors/peroxisome proliferator-activated receptor
obesity
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
18
02
2019
revised:
02
05
2019
pubmed:
3
5
2019
medline:
14
7
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO (MGL
Identifiants
pubmed: 31048404
pii: S0022-2275(20)31060-9
doi: 10.1194/jlr.M093369
pmc: PMC6602129
doi:
Substances chimiques
Adiponectin
0
Fatty Acids
0
Insulin
0
Peroxisome Proliferator-Activated Receptors
0
Triglycerides
0
Monoacylglycerol Lipases
EC 3.1.1.23
Glycerol
PDC6A3C0OX
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1284-1292Informations de copyright
Copyright © 2019 Tardelli et al.
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