Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
Aged
Aged, 80 and over
Dietary Supplements
Double-Blind Method
Female
Humans
Interleukin 1 Receptor Antagonist Protein
/ blood
Interleukin-6
/ blood
Leucine
/ pharmacology
Male
Middle Aged
Mobility Limitation
Muscle, Skeletal
/ drug effects
Sarcopenia
/ blood
Vitamin D
/ pharmacology
Whey Proteins
/ pharmacology
Aged
Cytokines
Dietary supplements
Leucine
Vitamin D
Whey proteins
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
18
01
2019
accepted:
16
04
2019
pubmed:
3
5
2019
medline:
19
7
2019
entrez:
4
5
2019
Statut:
ppublish
Résumé
A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4-9) and a body mass index of 20-30 kg/m IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks. We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.
Sections du résumé
BACKGROUND
BACKGROUND
A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited.
AIM
OBJECTIVE
To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis.
METHODS
METHODS
Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4-9) and a body mass index of 20-30 kg/m
RESULTS
RESULTS
IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks.
CONCLUSIONS
CONCLUSIONS
We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.
Identifiants
pubmed: 31049877
doi: 10.1007/s40520-019-01208-4
pii: 10.1007/s40520-019-01208-4
pmc: PMC6583678
doi:
Substances chimiques
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-6
0
Whey Proteins
0
Vitamin D
1406-16-2
Leucine
GMW67QNF9C
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
845-854Références
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