MRI-based tumour control probability in skull-base chordomas treated with carbon-ion therapy.
Chordoma
Diffusion Magnetic Resonance Imaging
Heavy ion radiotherapy
Skull base
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
14
01
2019
revised:
30
03
2019
accepted:
18
04
2019
pubmed:
6
5
2019
medline:
9
4
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
To derive personalized tumour control probability (TCP) models, using diffusion-weighted (DW-) MRI for defining initial tumour cellular density in skull-base chordoma patients undergoing carbon-ion radiotherapy (CIRT). 67 patients affected by skull-base chordoma were enrolled for a standardized CIRT treatment (70.4 Gy (RBE) prescription dose). Local control information was clinically assessed. For 20 of them, apparent diffusion coefficient (ADC) maps were computed from DW-MRI and then converted into cellular density. Radiosensitivity parameters (α, β) were estimated from the available data through an optimization procedure, taking advantage of a relationship observed between local control and the dose received by at least the 98% of the gross tumour volume. These parameters were fed into two poissonian TCP models, based on the LQ model, being the first (TCP The inclusion of the cellular density derived from ADC into TCP Both TCP
Identifiants
pubmed: 31051372
pii: S0167-8140(19)30370-6
doi: 10.1016/j.radonc.2019.04.018
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-37Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.