FcγRIIb on CD11c
Atherosclerosis
Dendritic cells
FcγRIIb
Hepatic cholesterol
Journal
Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
19
12
2018
revised:
08
04
2019
accepted:
12
04
2019
pubmed:
6
5
2019
medline:
26
6
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
Circulating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion. While global FcγR Bone marrow chimeras were generated by rescuing lethally irradiated Ldlr Quantitation of atherosclerosis in the proximal aorta demonstrated a 58% increase in female CD11c-Cre The absence of FcγRIIb expression on CD11c
Sections du résumé
BACKGROUND AND AIMS
Circulating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion. While global FcγR
METHODS
Bone marrow chimeras were generated by rescuing lethally irradiated Ldlr
RESULTS
Quantitation of atherosclerosis in the proximal aorta demonstrated a 58% increase in female CD11c-Cre
CONCLUSIONS
The absence of FcγRIIb expression on CD11c
Identifiants
pubmed: 31051414
pii: S0021-9150(19)30387-9
doi: 10.1016/j.atherosclerosis.2019.04.221
pmc: PMC8086422
mid: NIHMS1684594
pii:
doi:
Substances chimiques
CD11 Antigens
0
Fcgr2b protein, mouse
0
Receptors, IgG
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-119Subventions
Organisme : BLRD VA
ID : I01 BX002968
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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