Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
03 May 2019
03 May 2019
Historique:
received:
14
03
2018
accepted:
22
04
2019
entrez:
5
5
2019
pubmed:
6
5
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy, and it is associated with increased risk of morbidity in maternal-fetal outcomes. GDM is also associated with a higher risk to develop diabetes in the future. Diabetes-related autoantibodies (AABs) have been detected in a small percentage (usually less than 10%) of women with gestational diabetes. The prevalence in gestational diabetes of these autoimmune markers of type 1 diabetes (T1D) has been assessed in many studies, together with the risk of progression of AABs-positive GDM towards impaired glucose regulation (IFG or IGT) and overt diabetes after pregancy. The question whether it is necessary to test for T1D autoantibodies in all pregnancies with GDM is still debated. Here we examine the epidemiology of T1D autoantibodies in GDM, their clinical relevance in term of future risk of diabetes or impaired glucose regulation and in term of maternal-fetal outcomes, and discuss when it may be the most appropriate time to search for T1D autoantibodies in women with gestational diabetes.
Identifiants
pubmed: 31053128
doi: 10.1186/s12902-019-0373-4
pii: 10.1186/s12902-019-0373-4
pmc: PMC6500053
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44Subventions
Organisme : Sapienza Università di Roma
ID : Research Projects 2016
Organisme : Banca d'Italia
ID : Projects 2015
Organisme : Regione Autonoma della Sardegna
ID : Grant RAS 2007 n. CRP-59453
Organisme : Fondazione Banco di Sardegna
ID : Research Projects 2012-13 n. 834/2012-0742
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