Right atrial-right ventricular coupling in heart failure with preserved ejection fraction.
Feature tracking
Heart failure
Magnetic resonance imaging
Preserved ejection fraction
Pressure–volume-loops
Right atrium
Right heart
Journal
Clinical research in cardiology : official journal of the German Cardiac Society
ISSN: 1861-0692
Titre abrégé: Clin Res Cardiol
Pays: Germany
ID NLM: 101264123
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
20
01
2019
accepted:
23
04
2019
pubmed:
6
5
2019
medline:
23
10
2020
entrez:
5
5
2019
Statut:
ppublish
Résumé
Right ventricular (RV) function is prognostically relevant in heart failure with preserved ejection fraction (HFpEF) but data on profound assessment of RV and right atrial (RA) interaction in HFpEF are lacking. The current study characterizes RV and RA interaction using invasive pressure-volume-loop analysis and cardiac magnetic resonance imaging (CMR) data. We performed CMR and myocardial feature-tracking in 24 HFpEF patients and 12 patients without HFpEF. Invasive pressure-volume-loops were obtained to evaluate systolic and diastolic RV properties. RV early filling was determined from CMR RV volume-time curves. RV systolic function was slightly increased in HFpEF (RV EF 68 ± 8 vs. 60 ± 9%, p = 0.01), while no differences in RV stroke volume were found (45 ± 7 vs 42 ± 9 ml/m In compensated HFpEF patients RV early filling was impaired and compensated by increased RA booster pump function, while RV systolic function was preserved. Impaired RV diastology and RA-RV interaction were linked to impaired exercise tolerance and RA-RV-coupling seems to be independent of RV relaxation, suggestive of an independent pathophysiological contribution of RA dysfunction in HFpEF. NCT02459626 (www.clinicaltrials.gov).
Sections du résumé
BACKGROUND
BACKGROUND
Right ventricular (RV) function is prognostically relevant in heart failure with preserved ejection fraction (HFpEF) but data on profound assessment of RV and right atrial (RA) interaction in HFpEF are lacking. The current study characterizes RV and RA interaction using invasive pressure-volume-loop analysis and cardiac magnetic resonance imaging (CMR) data.
METHODS AND RESULTS
RESULTS
We performed CMR and myocardial feature-tracking in 24 HFpEF patients and 12 patients without HFpEF. Invasive pressure-volume-loops were obtained to evaluate systolic and diastolic RV properties. RV early filling was determined from CMR RV volume-time curves. RV systolic function was slightly increased in HFpEF (RV EF 68 ± 8 vs. 60 ± 9%, p = 0.01), while no differences in RV stroke volume were found (45 ± 7 vs 42 ± 9 ml/m
CONCLUSION
CONCLUSIONS
In compensated HFpEF patients RV early filling was impaired and compensated by increased RA booster pump function, while RV systolic function was preserved. Impaired RV diastology and RA-RV interaction were linked to impaired exercise tolerance and RA-RV-coupling seems to be independent of RV relaxation, suggestive of an independent pathophysiological contribution of RA dysfunction in HFpEF.
CLINICAL-TRIAL-REGISTRATION
UNASSIGNED
NCT02459626 (www.clinicaltrials.gov).
Identifiants
pubmed: 31053957
doi: 10.1007/s00392-019-01484-0
pii: 10.1007/s00392-019-01484-0
doi:
Banques de données
ClinicalTrials.gov
['NCT02459626']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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