Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes.

Alkaloids / chemistry Animals Benzophenanthridines / toxicity Berberine / analogs & derivatives Cells, Cultured Chelidonium / chemistry Chemical and Drug Induced Liver Injury / etiology Dose-Response Relationship, Drug Glutathione / metabolism Hepatocytes / drug effects Isoquinolines / toxicity Male Molecular Structure Primary Cell Culture Rats, Wistar Structure-Activity Relationship
Alkaloids Chelidonium majus Glutathione Hepatotoxicity Papaveraceae Rat hepatocytes Sanguinarine

Journal

Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027

Informations de publication

Date de publication:
01 Sep 2019
Historique:
received: 18 01 2019
revised: 22 04 2019
accepted: 29 04 2019
pubmed: 6 5 2019
medline: 14 6 2019
entrez: 5 5 2019
Statut: ppublish

Résumé

Phytomedicinal preparations containing extracts of the plant Chelidonium majus (Greater Celandine) have been used in the therapy of upper abdominal disorders. C. majus alkaloids (CAL) were suspected to be responsible for reported cases of liver symptoms including cases of acute liver failure in patients upon treatment with certain C. majus preparations. Based on these reports, a safe oral daily dose limit of not more than 2.5 mg CAL was established in the EU. However, C. majus extracts and individual CAL were not able to elicit similar adverse effects when given orally to pigs or rats. We found that CAL differ considerably in their cytotoxicity in rat hepatocytes in culture. The cationic congeners chelerythrine, coptisine and sanguinarine were the most toxic ones (EC

Identifiants

DOI: 10.1016/j.toxlet.2019.04.031 PMID: 31054355
pubmed: 31054355
pii: S0378-4274(19)30121-3
doi: 10.1016/j.toxlet.2019.04.031
pii:
doi:

Substances chimiques

Alkaloids 0
Benzophenanthridines 0
Isoquinolines 0
coptisine 0GCL71VN14
Berberine 0I8Y3P32UF
dihydrosanguinarine 3H1ZKG80F7
sanguinarine AV9VK043SS
chelerythrine E3B045W6X0
Glutathione GAN16C9B8O

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

91-97

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Lan Gao (L)

Food Chemistry and Toxicology, Faculty of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany.

Hans-Joachim Schmitz (HJ)

Food Chemistry and Toxicology, Faculty of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany.

Karl-Heinz Merz (KH)

Food Chemistry and Toxicology, Faculty of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany.

Dieter Schrenk (D)

Food Chemistry and Toxicology, Faculty of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany. Electronic address: schrenk@rhrk.uni-kl.de.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Characterization of the cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Characterization of the cytotoxicity of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Benzophénanthridines › Characterization of the cytotoxicity of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Alcaloïdes de type berbérine › Berbérine › Characterization of the cytotoxicity of...
questionsmedicales.fr › Cellules › Cellules cultivées › Characterization of the cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Ranunculales › Papaveraceae › Chelidonium › Characterization of the cytotoxicity of...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Characterization of the cytotoxicity of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Characterization of the cytotoxicity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Characterization of the cytotoxicity of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Characterization of the cytotoxicity of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Characterization of the cytotoxicity of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Characterization of the cytotoxicity of...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Characterization of the cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Characterization of the cytotoxicity of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Characterization of the cytotoxicity of...