Neurocognitive basis of repetition deficits in primary progressive aphasia.
Cortical thickness
Length
Phrase repetition
Primary progressive aphasia
Semantics
Journal
Brain and language
ISSN: 1090-2155
Titre abrégé: Brain Lang
Pays: Netherlands
ID NLM: 7506220
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
14
06
2018
revised:
10
04
2019
accepted:
13
04
2019
pubmed:
6
5
2019
medline:
30
11
2019
entrez:
6
5
2019
Statut:
ppublish
Résumé
Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
Identifiants
pubmed: 31055171
pii: S0093-934X(18)30142-1
doi: 10.1016/j.bandl.2019.04.003
pmc: PMC6669076
mid: NIHMS1039747
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-45Subventions
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052943
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100440
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC015544
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016345
Pays : United States
Organisme : NIDCD NIH HHS
ID : R03 DC013403
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016291
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS050915
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS050915
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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