Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy.
Adult
Biomarkers
/ blood
Cell-Free Nucleic Acids
/ blood
Cohort Studies
Female
Fetus
/ pathology
Humans
Hypertension, Pregnancy-Induced
/ blood
Infant, Newborn
Massachusetts
/ epidemiology
Placenta
/ physiopathology
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
Prenatal Diagnosis
Retrospective Studies
Cell-free DNA
Fetal fraction
Hypertensive disease in pregnancy
Placental dysfunction
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
02
01
2019
revised:
11
04
2019
accepted:
12
04
2019
entrez:
7
5
2019
pubmed:
6
5
2019
medline:
4
12
2019
Statut:
ppublish
Résumé
To examine the association of low fetal fraction of cell-free DNA (cfDNA) with placental compromise and adverse perinatal outcomes. This was a retrospective cohort utilizing a sample of convenience including 639 women undergoing cfDNA screening at our institution from January 2013 to January 2017. Low fetal fraction was defined as less than the 25th percentile. Indicators of placental compromise were examined individually and as a composite outcome, including hypertensive disease of pregnancy, intrauterine growth restriction, abruption, and oligohydramnios. Neonatal outcomes, including preterm delivery, low Apgar scores, and small for gestational age, also were examined. We calculated risk ratios (RR) and 95% confidence intervals (CI). Low fetal fraction was associated with placental compromise (RR 1.6 [CI 1.1-2.2]), hypertensive disease of pregnancy (RR 1.6 [CI 1.003-2.6]), and preeclampsia with severe features (RR 3.3 [CI 1.2-8.9]). Low fetal faction was not associated with preterm delivery, low Apgar scores, or small for gestational age. Low fetal fraction of cfDNA among asymptomatic women may serve as a predictor of subsequent placental dysfunction and hypertensive disease.
Identifiants
pubmed: 31056151
pii: S2210-7789(19)30001-7
doi: 10.1016/j.preghy.2019.04.002
pmc: PMC10066927
mid: NIHMS1878750
pii:
doi:
Substances chimiques
Biomarkers
0
Cell-Free Nucleic Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-153Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Informations de copyright
Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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