BIRC5 is a target for molecular imaging and detection of human pancreatic cancer.

Animals Biomarkers, Tumor / genetics Carcinoma, Pancreatic Ductal / diagnostic imaging Cell Line, Tumor Feasibility Studies Gene Expression Regulation, Neoplastic Humans Luciferases / genetics Male Mice, Nude Molecular Imaging Optical Imaging Pancreatic Neoplasms / diagnostic imaging Positron Emission Tomography Computed Tomography Predictive Value of Tests Promoter Regions, Genetic Survivin / genetics Thymidine Kinase / genetics Tumor Burden Up-Regulation X-Ray Microtomography
BIRC5 Gaussia luciferase Pancreatic cancer Super promoter Thymidine kinase, microPET/CT imaging

Journal

Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053

Informations de publication

Date de publication:
10 08 2019
Historique:
received: 13 02 2019
revised: 25 04 2019
accepted: 29 04 2019
pubmed: 7 5 2019
medline: 28 4 2020
entrez: 7 5 2019
Statut: ppublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer mortality with a dismal overall survival rate and an urgent need for detection of minute tumors. Current diagnostic modalities have high sensitivity and specificity for larger tumors, but not for minute PDAC. In this study, we test the feasibility of a precision diagnostic platform for detecting and localizing minute human PDAC in mice. This platform includes: 1) defining BIRC5 as an early PDAC-upregulated gene and utilizing an enhanced BIRC5 super-promoter to drive expression of dual Gaussia luciferase (GLuc) and sr39 thymidine kinase (sr39TK) reporter genes exponentially and specifically in PDAC; 2) utilizing a genetically-engineered AAV

Identifiants

DOI: 10.1016/j.canlet.2019.04.036 PMID: 31059751
pubmed: 31059751
pii: S0304-3835(19)30273-3
doi: 10.1016/j.canlet.2019.04.036
pii:
doi:

Substances chimiques

BIRC5 protein, human 0
Biomarkers, Tumor 0
Survivin 0
Luciferases EC 1.13.12.-
Thymidine Kinase EC 2.7.1.21

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

10-19

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Shi-He Liu (SH)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Yeahwa Hong (Y)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Stephen Markowiak (S)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Robbi Sanchez (R)

Department of Surgery, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Justin Creeden (J)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

John Nemunaitis (J)

Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Andrea Kalinoski (A)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

James Willey (J)

Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Paul Erhardt (P)

Department of Pharmacology-Medicinal/Biological Chemistry, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA.

Jason Lee (J)

Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, 90095, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Michael van Dam (M)

Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, 90095, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, 90095, USA.

F Charles Brunicardi (FC)

Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, 43614, USA. Electronic address: francis.brunicardi@utoledo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études de faisabilité › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Luciferases › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines IAP › Survivine › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Thymidine kinase › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › BIRC5 is a target for molecular imaging and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › BIRC5 is a target for molecular imaging and...