Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis.
Streptococcus pneumoniae
brain infection
hearing loss
meningitis
neuroinflammation
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
30
01
2019
accepted:
30
04
2019
pubmed:
8
5
2019
medline:
19
5
2020
entrez:
8
5
2019
Statut:
epublish
Résumé
Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities. An excessive inflammatory reaction drives the pathophysiology, leading to brain damage and neurologic sequelae. We aimed to improve the outcome of experimental PM by simultaneously targeting different pathophysiological mechanisms with combined adjunctive therapies previously shown to be neuroprotective.
Identifiants
pubmed: 31061158
pii: AAC.00220-19
doi: 10.1128/AAC.00220-19
pmc: PMC6591596
pii:
doi:
Substances chimiques
Ceftriaxone
75J73V1629
Doxycycline
N12000U13O
Daptomycin
NWQ5N31VKK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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