Skin autofluorescence as a measure of advanced glycation end product levels is associated with carotid atherosclerotic plaque burden in an elderly population.
Age Factors
Aged
Biomarkers
/ metabolism
Carotid Artery Diseases
/ diagnostic imaging
Carotid Intima-Media Thickness
Cross-Sectional Studies
Female
Glycation End Products, Advanced
/ metabolism
Humans
Luminescent Measurements
Male
Plaque, Atherosclerotic
Prevalence
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Skin
/ metabolism
Sweden
/ epidemiology
Advanced glycation end products
atherosclerosis
diabetes
plaque area
skin autofluorescence
Journal
Diabetes & vascular disease research
ISSN: 1752-8984
Titre abrégé: Diab Vasc Dis Res
Pays: England
ID NLM: 101234011
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
9
5
2019
medline:
3
1
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
Advanced glycation end product is an established risk marker in diabetic vascular disease, but its possible associations with atherosclerosis in a general population are yet to be investigated. We studied the degree of carotid atherosclerosis and its association with skin autofluorescence in an elderly population. Carotid ultrasound and skin autofluorescence measurements were performed in a subpopulation within the 'Malmö Diet and Cancer Cardiovascular Cohort' re-examination study ( Each 1 standard deviation increment of skin autofluorescence was associated with increased risk of prevalent large plaques (odds ratio, 1.32; 95% confidence interval, 1.05-1.66; In an elderly population, skin autofluorescence was associated with increasing degree of carotid atherosclerosis measured as total plaque area, independently of diabetes and cardiovascular risk factors.
Sections du résumé
BACKGROUND
Advanced glycation end product is an established risk marker in diabetic vascular disease, but its possible associations with atherosclerosis in a general population are yet to be investigated. We studied the degree of carotid atherosclerosis and its association with skin autofluorescence in an elderly population.
METHODS
Carotid ultrasound and skin autofluorescence measurements were performed in a subpopulation within the 'Malmö Diet and Cancer Cardiovascular Cohort' re-examination study (
RESULTS
Each 1 standard deviation increment of skin autofluorescence was associated with increased risk of prevalent large plaques (odds ratio, 1.32; 95% confidence interval, 1.05-1.66;
CONCLUSION
In an elderly population, skin autofluorescence was associated with increasing degree of carotid atherosclerosis measured as total plaque area, independently of diabetes and cardiovascular risk factors.
Identifiants
pubmed: 31064217
doi: 10.1177/1479164119845319
doi:
Substances chimiques
Biomarkers
0
Glycation End Products, Advanced
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM