Functions of estrogen and estrogen receptor signaling on skeletal muscle.
Estrogen
Exercise endurance
Gene regulation
Mitochondria
Skeletal muscle
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
27
03
2019
accepted:
03
05
2019
pubmed:
9
5
2019
medline:
21
11
2019
entrez:
9
5
2019
Statut:
ppublish
Résumé
Activity of estrogen, a sex steroid hormone, is not only limited to the reproductive organs but also involves other organs and tissues, including skeletal muscle. In postmenopausal women, estrogen decline causes endocrine and metabolic dysfunction, leading to a predisposition to osteoporosis, metabolic syndrome, and decreased muscle mass and strength. The decline in skeletal muscle mass often associates with sarcopenia, a popular condition observed in fragile elder people. In addition, varying estrogen levels associated with the menstrual phases may modulate exercise performance in women. Estrogen is thus considered to play a crucial role in skeletal muscle homeostasis and exercise capacity, although its precise mechanisms remain to be elucidated. In this article, we review the role of estrogen in the skeletal muscle, outlining the proposed molecular mechanisms. We especially focus on the current understanding of estrogen actions on mitochondria metabolism in skeletal muscle.
Identifiants
pubmed: 31067490
pii: S0960-0760(19)30185-2
doi: 10.1016/j.jsbmb.2019.105375
pii:
doi:
Substances chimiques
Estrogens
0
Receptors, Estrogen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105375Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.