A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters.

Cell Line Drug Interactions Humans In Vitro Techniques Membrane Transport Proteins / drug effects

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
07 2019
Historique:
received: 08 01 2019
accepted: 02 05 2019
pubmed: 10 5 2019
medline: 28 5 2020
entrez: 10 5 2019
Statut: ppublish

Résumé

Preincubation of a drug transporter with its inhibitor in a cell-based assay may result in the apparent enhancement of the inhibitory potency. Currently, limited data are available on potentiation of transporter inhibition by preincubation (PTIP) for clinically relevant solute-carrier transporters other than OATP1B1 and OATP1B3. Therefore, PTIP was examined systematically using OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, and MATE2-K cell lines. IC

Identifiants

DOI: 10.1124/dmd.118.085993 PMID: 31068368
pubmed: 31068368
pii: dmd.118.085993
doi: 10.1124/dmd.118.085993
doi:

Substances chimiques

Membrane Transport Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

768-778

Informations de copyright

Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Péter Tátrai (P)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.) tatrai@solvo.com.
ORCID: 0000-0001-9726-1992

Patrick Schweigler (P)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Birk Poller (B)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Norbert Domange (N)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Roelof de Wilde (R)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Imad Hanna (I)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Zsuzsanna Gáborik (Z)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.).

Felix Huth (F)

Solvo Biotechnology, Budapest, Hungary (P.T., R.d.W., Z.G.); Novartis Institutes for Biomedical Research, Basel, Switzerland (P.S., B.P., N.D., F.H.); and Novartis Institutes for Biomedical Research, East Hanover, New Jersey (I.H.) felix.huth@novartis.com.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › A Systematic In Vitro Investigation of the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › A Systematic In Vitro Investigation of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Systematic In Vitro Investigation of the...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › A Systematic In Vitro Investigation of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › A Systematic In Vitro Investigation of the...