Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.
EAE
T cell
autoimmunity
proteomics
relapse
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 05 2019
21 05 2019
Historique:
pubmed:
10
5
2019
medline:
31
3
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are emerging as potent mediators of intercellular communication with roles in inflammation and disease. In this study, we examined the role of EVs from blood plasma (pEVs) in an experimental autoimmune encephalomyelitis mouse model of central nervous system demyelination. We determined that pEVs induced a spontaneous relapsing-remitting disease phenotype in MOG
Identifiants
pubmed: 31068461
pii: 1816911116
doi: 10.1073/pnas.1816911116
pmc: PMC6535008
doi:
Substances chimiques
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10488-10493Subventions
Organisme : NINDS NIH HHS
ID : R21 NS087578
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097976
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS099359
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Conflict of interest statement: K.A. is a scientific cofounder of MedaRed, Inc. Her interests are managed by the Gladstone Institutes in accordance with its conflict of interest policy.
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