Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
14
01
2019
accepted:
27
03
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
11
7
2019
Statut:
ppublish
Résumé
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
Identifiants
pubmed: 31068712
doi: 10.1038/s41591-019-0437-z
pii: 10.1038/s41591-019-0437-z
pmc: PMC6557439
mid: NIHMS1525650
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
730-733Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116884
Pays : United States
Références
Probl Tuberk. 1975;(4):75-9
pubmed: 810794
Proc Am Thorac Soc. 2009 Dec;6(8):619-33
pubmed: 20008865
Evol Med Public Health. 2018 Mar 08;2018(1):60-66
pubmed: 29588855
J Virol. 2015 Aug;89(16):8107-10
pubmed: 26018169
PLoS One. 2008;3(12):e3957
pubmed: 19088849
Mol Cell. 2013 Jan 24;49(2):237-48
pubmed: 23246436
Tuberculosis (Edinb). 2019 Mar;115:14-23
pubmed: 30948168
PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2183
pubmed: 23638204
Czech Med. 1981;4(4):209-14
pubmed: 7327068
Semin Respir Crit Care Med. 2018 Jun;39(3):383-391
pubmed: 30071553
F1000Prime Rep. 2014 Nov 04;6:107
pubmed: 25580261
Transpl Infect Dis. 2018 Apr;20(2):e12835
pubmed: 29359872
Virology. 2012 Dec 20;434(2):187-201
pubmed: 23084079
Pediatr Pulmonol. 2017 Nov;52(S48):S29-S36
pubmed: 28881094
Int J Antimicrob Agents. 2019 Jan;53(1):16-21
pubmed: 30236954
Front Microbiol. 2018 Aug 30;9:2029
pubmed: 30214436
J Med Microbiol. 2006 Jan;55(Pt 1):37-42
pubmed: 16388028
Antimicrob Agents Chemother. 2017 Sep 22;61(10):
pubmed: 28807909