An in vitro model for studying CNS white matter: functional properties and experimental approaches.
(re)myelination
microelectrode array
microglia
semi-high throughput
siRNA
spinal cord
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
15
01
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
4
6
2020
Statut:
epublish
Résumé
The normal development and maintenance of CNS white matter, and its responses to disease and injury, are defined by synergies between axons, oligodendrocytes, astrocytes and microglia, and further influenced by peripheral components such as the gut microbiome and the endocrine and immune systems. Consequently, mechanistic insights, therapeutic approaches and safety tests rely ultimately on
Identifiants
pubmed: 31069065
doi: 10.12688/f1000research.16802.1
pmc: PMC6489523
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117Subventions
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/L000423/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
No competing interests were disclosed.
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