A
1H NMR
Animal model
Aqueous humour
Metabolomics
PMI estimation
Journal
Metabolomics : Official journal of the Metabolomic Society
ISSN: 1573-3890
Titre abrégé: Metabolomics
Pays: United States
ID NLM: 101274889
Informations de publication
Date de publication:
08 05 2019
08 05 2019
Historique:
received:
28
01
2019
accepted:
24
04
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
2
5
2020
Statut:
epublish
Résumé
The estimation of the time since death, or post-mortem interval (PMI), still remains a main conundrum in forensic science. Several approaches have been so far proposed from either a qualitative or a quantitative point of view, but they still lack reliability and robustness. Recently, metabolomics has shown to be a potential tool to investigate the time-related post-mortem metabolite modifications in animal models. Here we propose, for the first time, the use of a AH samples were collected at different times after death (from 118 to 1429 min). A multivariate calibration model was built to estimate PMI on the basis of the metabolite content of the samples. The model was validated with an independent test set, obtaining a prediction error of 59 min for PMI < 500 min, 104 min for PMI from 500 to 1000 min, and 118 min for PMI > 1000 min. Moreover, the metabolomic approach suggested a picture of the mechanisms underlying the post-mortem biological modifications, highlighting the role played by taurine, choline, and succinate. The time-related modifications of the
Identifiants
pubmed: 31069551
doi: 10.1007/s11306-019-1533-2
pii: 10.1007/s11306-019-1533-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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