Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy.
Aged
Brain Mapping
Cerebellum
/ physiopathology
Cerebral Cortex
/ physiopathology
Cognition
Cognition Disorders
/ etiology
Executive Function
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple System Atrophy
/ complications
Nerve Net
/ physiopathology
Neuropsychological Tests
Psychomotor Performance
Cerebellum
Cognition
Functional connectivity
Multiple system atrophy
Resting-state network
Journal
Cerebellum (London, England)
ISSN: 1473-4230
Titre abrégé: Cerebellum
Pays: United States
ID NLM: 101089443
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
pubmed:
10
5
2019
medline:
14
1
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
We aimed to elucidate the effect of cerebellar degeneration in relation to cognition in multiple system atrophy (MSA). Thirty-two patients diagnosed with probable MSA and 32 age- and gender-matched healthy controls (HCs) were enrolled. We conducted voxel-based morphometry (VBM) for anatomical images and independent component analysis (ICA), dual-regression analysis, and seed-based analysis for functional images with voxel-wise gray matter correction. In the MSA group, a widespread cerebellar volume loss was observed. ICA and dual-regression analysis showed lower functional connectivity (FC) in the left executive control and salience networks in regions located in the cerebellum. Seed-based analysis using the identified cerebellar regions as seeds showed extensive disruptions in cerebello-cerebral networks. Global cognitive scores correlated with the FC values between the right lobules VI/crus I and the medial prefrontal/anterior cingulate cortices and between the same region and the amygdala/parahippocampal gyrus. Our study indicates that cerebellar degeneration in MSA causes segregation of cerebellar-cerebral networks. Furthermore, the cognitive deficits in MSA may be driven by decreased cerebello-prefrontal and cerebello-amygdaloid functional connections.
Identifiants
pubmed: 31069705
doi: 10.1007/s12311-019-01031-7
pii: 10.1007/s12311-019-01031-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
770-780Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : Brain Protein Aging and Dementia Control 26117002
Organisme : Japan Agency for Medical Research and Development
ID : None
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