Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ drug effects
Antineoplastic Agents, Phytogenic
/ isolation & purification
Cell Line, Tumor
Cell Proliferation
/ drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Components, Aerial
/ chemistry
Solanaceae
/ chemistry
Structure-Activity Relationship
Withanolides
/ isolation & purification
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
24 05 2019
24 05 2019
Historique:
pubmed:
10
5
2019
medline:
29
8
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
Four new withanolides (2-5), together with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide (1), were isolated from the aerial parts of Eriolarynx iochromoides. The antiproliferative activity of all compounds purified from E. iochromoides together with four withaphysalins and four physangulidines isolated previously from three Deprea species were evaluated against human solid tumor cell lines. Four withanolides showed antiproliferative activity comparable in potency to cisplatin. Selectivity toward cancer cells and interaction with P-glycoprotein of the active withanolides were evaluated.
Identifiants
pubmed: 31070367
doi: 10.1021/acs.jnatprod.9b00117
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Antineoplastic Agents, Phytogenic
0
Withanolides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM