Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes.
Animals
Anthraquinones
/ pharmacology
Cell Line
Glucose
/ metabolism
Glucose Transporter Type 4
/ metabolism
Glycoside Hydrolase Inhibitors
/ pharmacology
Hypoglycemic Agents
/ pharmacology
Insulin
/ metabolism
Kinetics
Mice
Muscle Fibers, Skeletal
/ drug effects
Protein Transport
Signal Transduction
/ drug effects
Anthraquinone
Antidiabetic effect
GLUT4 translocation
Insulin-like signaling pathway
Rubia philippinensis
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
28
12
2018
revised:
03
04
2019
accepted:
04
05
2019
pubmed:
10
5
2019
medline:
30
7
2019
entrez:
10
5
2019
Statut:
ppublish
Résumé
This study assesses the ability of anthraquinone derivative, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTAQ) to decrease postprandial hyperglycemia or enhance glucose uptake and to elucidate the underlying molecular mechanism. We investigated α-glucosidase inhibition, glucose uptake, and translocation of glucose transporter 4 (GLUT4) in C2C12 myotubes. The data indicate that MTAQ strongly inhibited α-glucosidase activity in a concentration-dependent manner, with an IC
Identifiants
pubmed: 31071387
pii: S0278-6915(19)30272-8
doi: 10.1016/j.fct.2019.05.005
pii:
doi:
Substances chimiques
2-methyl-1,3,6-trihydroxy-9,10-anthraquinone
0
Anthraquinones
0
Glucose Transporter Type 4
0
Glycoside Hydrolase Inhibitors
0
Hypoglycemic Agents
0
Insulin
0
Slc2a4 protein, mouse
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Pagination
337-343Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.