C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature.
Atrial Natriuretic Factor
/ genetics
Cardiovascular System
/ metabolism
Endothelial Cells
/ metabolism
Ethanolamines
/ metabolism
Humans
Myocardium
/ metabolism
Myocytes, Cardiac
/ metabolism
Natriuretic Peptide, Brain
/ genetics
Natriuretic Peptide, C-Type
/ genetics
Paracrine Communication
/ genetics
Phenethylamines
/ metabolism
Receptors, Atrial Natriuretic Factor
/ genetics
Natriuretic peptide
angiogenesis
cardiomyocyte
endothelial cell
fibroblast
heart failure
hypertension
inflammation
vascular
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 May 2019
08 May 2019
Historique:
received:
15
04
2019
revised:
30
04
2019
accepted:
02
05
2019
entrez:
11
5
2019
pubmed:
11
5
2019
medline:
31
8
2019
Statut:
epublish
Résumé
C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions in the cardiovascular system. These roles are conveyed via two cognate receptors, natriuretic peptide receptor B (NPR-B) and natriuretic peptide receptor C (NPR-C), which activate different signalling pathways that mediate complementary yet distinct cellular responses. Traditionally, CNP has been deemed the endothelial component of the natriuretic peptide system, while its sibling peptides, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), are considered the endocrine guardians of cardiac function and blood volume. However, accumulating evidence indicates that CNP not only modulates vascular tone and blood pressure, but also governs a wide range of cardiovascular effects including the control of inflammation, angiogenesis, smooth muscle and endothelial cell proliferation, atherosclerosis, cardiomyocyte contractility, hypertrophy, fibrosis, and cardiac electrophysiology. This review will focus on the novel physiological functions ascribed to CNP, the receptors/signalling mechanisms involved in mediating its cardioprotective effects, and the development of therapeutics targeting CNP signalling pathways in different disease pathologies.
Identifiants
pubmed: 31072047
pii: ijms20092281
doi: 10.3390/ijms20092281
pmc: PMC6539462
pii:
doi:
Substances chimiques
Ethanolamines
0
Phenethylamines
0
Natriuretic Peptide, Brain
114471-18-0
Natriuretic Peptide, C-Type
127869-51-6
Atrial Natriuretic Factor
85637-73-6
Receptors, Atrial Natriuretic Factor
EC 4.6.1.2
atrial natriuretic factor receptor B
EC 4.6.1.2
atrial natriuretic factor receptor C
EC 4.6.1.2
bamethan
Y08ZFJ9TFK
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : RG/16/7/32357
Pays : United Kingdom
Déclaration de conflit d'intérêts
Adrian J. Hobbs is a scientific advisory board member for Palatin Technologies Inc and is a named inventor on a patent describing NPR-C agonists. The other authors report no conflicts.
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