Amino Acid-Functionalized Polyelectrolyte Films as Bioactive Surfaces for Cell Adhesion.
Amino Acids
/ chemistry
Cell Adhesion
/ drug effects
Cell Line, Tumor
Humans
Hydrogen-Ion Concentration
Maleates
/ chemistry
Microscopy, Electron, Scanning
Nanostructures
/ chemistry
Polyelectrolytes
/ chemistry
Polymers
/ chemistry
Polystyrenes
/ chemistry
Spectroscopy, Fourier Transform Infrared
Surface Properties
Wettability
SH-SY5Y neuroblastoma
amino acid
cell adhesion
functionalization
polyelectrolytes
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
05 Jun 2019
05 Jun 2019
Historique:
pubmed:
11
5
2019
medline:
4
12
2019
entrez:
11
5
2019
Statut:
ppublish
Résumé
Surfaces were prepared with polyelectrolyte derivatives of poly(styrene- alt-maleic anhydride) (PSMA) functionalized with amino acids of different hydropathy indices, with the aim of evaluating the effect of the chemical functionality of polyelectrolytes on SH-SY5Y neuroblastoma cell adhesion. Functionalizing PSMA derivatives with l-glutamine, l-methionine, and l-tyrosine yielded PSMA-Gln, PSMA-Met, and PSMA-Tyr polyelectrolytes, respectively. We first studied the adsorption behavior of PSMA functionalized with amino acids on silicon wafer surfaces modified with 3-aminopropyltriethoxysilane at pH 4.0 and 7.0 and at low and high ionic strengths. The highest rate of polyelectrolyte adsorption was at pH 4.0 and high ionic strength and was higher with the glutamine and tyrosine films. The advance contact angles (θ
Identifiants
pubmed: 31074956
doi: 10.1021/acsami.9b02503
doi:
Substances chimiques
Amino Acids
0
Maleates
0
Polyelectrolytes
0
Polymers
0
Polystyrenes
0
poly(styrene-alt-maleic anhydride)
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM