Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease.
Animals
Anti-Bacterial Agents
/ administration & dosage
Anti-Inflammatory Agents
/ administration & dosage
Bronchi
/ immunology
Cystic Fibrosis
/ complications
Dose-Response Relationship, Drug
Humans
Imino Sugars
/ administration & dosage
Inflammation
/ prevention & control
Inhibitory Concentration 50
Mice
Neutrophils
/ immunology
Pseudomonas Infections
/ complications
Pseudomonas aeruginosa
/ drug effects
Stereoisomerism
beta-Glucosidase
/ antagonists & inhibitors
Cystic fibrosis
NLGase
Polymeric triphenylphosphine
l-Deoxyiminosugars
l-NBDNJ
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Aug 2019
01 Aug 2019
Historique:
received:
31
01
2019
revised:
04
04
2019
accepted:
21
04
2019
pubmed:
11
5
2019
medline:
16
7
2019
entrez:
11
5
2019
Statut:
ppublish
Résumé
In the frame of a research program aimed to explore the relationship between chirality of iminosugars and their therapeutic potential, herein we report the synthesis of N-akyl l-deoxyiminosugars and the evaluation of the anti-inflammatory properties of selected candidates for the treatment of Pseudomonas aeruginosa infections in Cystic Fibrosis (CF) lung disease. Target glycomimetics were prepared by the shortest and most convenient approach reported to date, relying on the use of the well-known PS-TPP/I
Identifiants
pubmed: 31075609
pii: S0223-5234(19)30379-4
doi: 10.1016/j.ejmech.2019.04.061
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Inflammatory Agents
0
Imino Sugars
0
beta-Glucosidase
EC 3.2.1.21
beta-glucosidase 2, mouse
EC 3.2.1.21
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-71Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.