New approach to investigate Common Variable Immunodeficiency patients using spectrochemical analysis of blood.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 05 2019
10 05 2019
Historique:
received:
14
01
2019
accepted:
04
04
2019
entrez:
12
5
2019
pubmed:
12
5
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Common variable immune deficiency (CVID) is a primary immunodeficiency disease, characterized by hypogammaglobulinemia, recurrent infections and various complications. The clinical heterogeneity of CVID has hindered identification of an underlying immune defect; diagnosis relies on clinical judgement, alongside evidence-based criteria. The lack of pathognomonic clinical or laboratory features leads to average diagnostic delays of 5 years or more from the onset. Vibrational spectroscopic techniques such as Fourier-transform infrared (FTIR) spectroscopy have recently gained increasing clinical importance, being rapid-, non-invasive and inexpensive methods to obtain information on the content of biological samples. This has led us to apply FTIR spectroscopy to the investigation of blood samples from a cohort of CVID patients; revealing spectral features capable of stratifying CVID patients from healthy controls with sensitivities and specificities of 97% and 93%, respectively for serum, and 94% and 95%, respectively for plasma. Furthermore we identified several discriminating spectral biomarkers; wavenumbers in regions indicative of nucleic acids (984 cm
Identifiants
pubmed: 31076587
doi: 10.1038/s41598-019-43196-5
pii: 10.1038/s41598-019-43196-5
pmc: PMC6510896
doi:
Substances chimiques
Biomarkers
0
Banques de données
figshare
['10.6084/m9.figshare.7751309']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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