Prediction of prolonged ventilator dependence in preterm infants.
Carbon dioxide levels
Compliance
Gestational age
Resistance
Tidal volume
Ventilator dependence
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
22
01
2019
accepted:
26
04
2019
revised:
18
04
2019
pubmed:
12
5
2019
medline:
31
1
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
Volutrauma is an important factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Our aims were to identify risk factors in the first 24 h for prolonged ventilator dependence and assess volume delivery and carbon dioxide levels in infants with evolving BPD. A retrospective study was undertaken of 41 infants born at less than 32 weeks of gestational age (GA). A higher tidal volume, minute volume and resistance and a lower GA, birth weight and compliance were associated with a significantly higher risk of ventilator dependence at 28 days. The strongest relationships were with birth weight (area under the receiver operating characteristic curve, AUROC = 0.771) and GA (AUROC = 0.813). Tidal volume remained significantly higher after adjusting for GA in those who remained ventilator dependent at 28 days. The 18 who remained ventilator dependent at 28 days had increased mean carbon dioxide (PCO
Identifiants
pubmed: 31076842
doi: 10.1007/s00431-019-03394-9
pii: 10.1007/s00431-019-03394-9
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1063-1068Subventions
Organisme : NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
ID : N/A
Références
Am J Physiol. 1999 Jul;277(1):L167-73
pubmed: 10409244
Intensive Care Med. 1999 Jul;25(7):705-13
pubmed: 10470574
Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9
pubmed: 11401896
Arch Dis Child Fetal Neonatal Ed. 2009 Jul;94(4):F279-82
pubmed: 19060010
Am J Respir Crit Care Med. 2011 Jun 15;183(12):1715-22
pubmed: 21471086
Early Hum Dev. 1990 Apr;22(1):51-6
pubmed: 2335142
Clin Exp Pharmacol Physiol. 2013 Nov;40(11):765-73
pubmed: 23414429
Neonatology. 2013;104(4):265-74
pubmed: 24107385
N Engl J Med. 2014 Mar 20;370(12):1121-1130
pubmed: 24645944
Am J Perinatol. 2017 Jan;34(2):155-163
pubmed: 27355979
Early Hum Dev. 2017 May;108:29-32
pubmed: 28371672
Cochrane Database Syst Rev. 2017 Oct 17;10:CD003666
pubmed: 29039883
Cochrane Database Syst Rev. 2017 Oct 24;10:CD001145
pubmed: 29063594
Pediatr Pulmonol. 2018 Jan;53(1):57-63
pubmed: 29152912
Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1):F46-F49
pubmed: 29305407
J Biomech. 2019 May 9;88:186-189
pubmed: 30922612
Am J Dis Child. 1986 May;140(5):449-52
pubmed: 3962939
Pediatr Res. 1997 Sep;42(3):348-55
pubmed: 9284276
J Appl Physiol (1985). 1997 Oct;83(4):1054-61
pubmed: 9338410
Am J Respir Crit Care Med. 1998 Jan;157(1):294-323
pubmed: 9445314
Am J Physiol. 1998 Dec;275(6):L1040-50
pubmed: 9843840