Neuronal loss or dysfunction in patients with early Lyme neuroborreliosis: a proton magnetic resonance spectroscopy study of the brain.
1H-magnetic resonance spectroscopy,1H-MRS
Borrelia burgdorferi
Lyme neuroborreliosis
Magnetic resonance spectroscopy
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
21
01
2019
accepted:
03
05
2019
revised:
08
04
2019
pubmed:
12
5
2019
medline:
10
1
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
We hypothesized that since Borrelia burgdorferi causes systemic inflammation and infects the brain, it may lead to alterations in cerebral metabolism, as measured by Twenty-six patients diagnosed with early LNB and twenty-six healthy volunteers as a control group have been involved in the study. All of them underwent routine MRI protocol using 3.0-T MRI scanner. We found a statistically significant decrease of the N-acetylaspartate/creatine ratio within the anterior part of the right and left frontal lobes (p ≤ 0.001 and p = 0.001 respectively) and in the posterior part of the right and left frontal lobes (p ≤ 0.001 and 0.031) in the patients with LNB. A significant reduction in NAA/Cr ratio in comparison with the controls suggests the presence of diffuse neuronal loss in patients with early LNB.
Sections du résumé
BACKGROUND
BACKGROUND
We hypothesized that since Borrelia burgdorferi causes systemic inflammation and infects the brain, it may lead to alterations in cerebral metabolism, as measured by
METHODS
METHODS
Twenty-six patients diagnosed with early LNB and twenty-six healthy volunteers as a control group have been involved in the study. All of them underwent routine MRI protocol using 3.0-T MRI scanner.
RESULTS
RESULTS
We found a statistically significant decrease of the N-acetylaspartate/creatine ratio within the anterior part of the right and left frontal lobes (p ≤ 0.001 and p = 0.001 respectively) and in the posterior part of the right and left frontal lobes (p ≤ 0.001 and 0.031) in the patients with LNB.
CONCLUSION
CONCLUSIONS
A significant reduction in NAA/Cr ratio in comparison with the controls suggests the presence of diffuse neuronal loss in patients with early LNB.
Identifiants
pubmed: 31076877
doi: 10.1007/s00415-019-09359-0
pii: 10.1007/s00415-019-09359-0
pmc: PMC6647218
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1937-1943Subventions
Organisme : Medical University of Białystok
ID : N/ST/ZB/16/004/1127
Références
Folia Neuropathol. 1999;37(1):43-51
pubmed: 10337063
Nucl Med Commun. 2002 Aug;23(8):773-7
pubmed: 12124483
Neuroradiology. 2004 Jan;46(1):26-30
pubmed: 14663542
Neurol Neurochir Pol. 2004 Jul-Aug;38(4):265-70
pubmed: 15383953
J Hepatol. 2004 Nov;41(5):845-51
pubmed: 15519659
Brain. 2005 Dec;128(Pt 12):2933-40
pubmed: 16195241
Mol Med. 2008 Mar-Apr;14(3-4):205-12
pubmed: 18097481
Am J Pathol. 2008 Nov;173(5):1415-27
pubmed: 18832582
Arch Neurol. 1991 Aug;48(8):832-6
pubmed: 1898257
AJNR Am J Neuroradiol. 2009 Jun;30(6):1079-87
pubmed: 19346313
Radiology. 2009 Oct;253(1):167-73
pubmed: 19587309
Arthritis Rheum. 2009 Nov;60(11):3190-5
pubmed: 19877035
Eur J Neurol. 2010 Jan;17(1):8-16, e1-4
pubmed: 19930447
Neurobiol Dis. 2010 Mar;37(3):534-41
pubmed: 19944760
Euro Surveill. 2011 Jul 07;16(27):null
pubmed: 21794218
Clin Nucl Med. 2012 Sep;37(9):e219-22
pubmed: 22889796
J Hepatol. 2013 Oct;59(4):651-7
pubmed: 23680314
Radiology. 2014 Mar;270(3):658-79
pubmed: 24568703
Am J Pathol. 2015 May;185(5):1344-60
pubmed: 25892509
Nat Rev Neurol. 2015 Aug;11(8):446-56
pubmed: 26215621
BMC Neurol. 2016 Jul 12;16:99
pubmed: 27405321
Front Neurol. 2017 Apr 20;8:146
pubmed: 28473801
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Brain. 1994 Feb;117 ( Pt 1):49-58
pubmed: 8149214