Multimodal characterization of the human nucleus accumbens.
Accumbens
CLARITY
Computational modeling
Core
DBS
Shell
Tractography
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
05
01
2019
revised:
27
04
2019
accepted:
07
05
2019
pubmed:
12
5
2019
medline:
13
2
2020
entrez:
12
5
2019
Statut:
ppublish
Résumé
Dysregulation of the nucleus accumbens (NAc) is implicated in numerous neuropsychiatric disorders. Treatments targeting this area directly (e.g. deep brain stimulation) demonstrate variable efficacy, perhaps owing to non-specific targeting of a functionally heterogeneous nucleus. Here we provide support for this notion, first observing disparate behavioral effects in response to direct simulation of different locations within the NAc in a human patient. These observations motivate a segmentation of the NAc into subregions, which we produce from a diffusion-tractography based analysis of 245 young, unrelated healthy subjects. We further explore the mechanism of these stimulation-induced behavioral responses by identifying the most probable subset of axons activated using a patient-specific computational model. We validate our diffusion-based segmentation using evidence from several modalities, including MRI-based measures of function and microstructure, human post-mortem immunohistochemical staining, and cross-species comparison of cortical-NAc projections that are known to be conserved. Finally, we visualize the passage of individual axon bundles through one NAc subregion in a post-mortem human sample using CLARITY 3D histology corroborated by 7T tractography. Collectively, these findings extensively characterize human NAc subregions and provide insight into their structural and functional distinctions with implications for stereotactic treatments targeting this region.
Identifiants
pubmed: 31077843
pii: S1053-8119(19)30402-1
doi: 10.1016/j.neuroimage.2019.05.019
pmc: PMC7341972
mid: NIHMS1595324
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-149Subventions
Organisme : NINDS NIH HHS
ID : UH3 NS103446
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS040894
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095985
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH116484
Pays : United States
Organisme : NINDS NIH HHS
ID : L30 NS079358
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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