Association of Receptor for advanced glycation end products G82S polymorphism with chronic periodontitis in type II diabetic and non-diabetic South Indians.
Chronic periodontitis
Genotype
Phenotype
Receptor for advanced glycation end products
Single nucleotide polymorphism
Type II diabetes
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
05 Aug 2019
05 Aug 2019
Historique:
received:
03
01
2019
revised:
20
04
2019
accepted:
30
04
2019
pubmed:
13
5
2019
medline:
25
6
2019
entrez:
13
5
2019
Statut:
ppublish
Résumé
AIM The current study investigated the association of RAGE G82S polymorphism with chronic periodontitis in South Indians with and without type II Diabetes mellitus. 405 individuals were enrolled into 3 groups-systemically and periodontally healthy with no attachment loss (n = 135), generalized chronic periodontitis (n = 135)and generalized chronic periodontitis with type II diabetes mellitus(n = 135). Periodontal clinical parameters were recorded. RFLP-PCR was utilized for genotyping. Frequencies of genotype GG, GA and AA were 133, 2, 0 in group I respectively, 131, 4, 0 in group II respectively and 118, 13, 4 in group III respectively. Pearson's Chi squared test demonstrated a significant difference in the genotype distribution between the three groups (χ RAGE G82S gene polymorphism confers susceptibility to generalized chronic periodontitis in type II diabetic subjects of South Indian Tamilian ethnicity.
Identifiants
pubmed: 31078654
pii: S0378-1119(19)30449-4
doi: 10.1016/j.gene.2019.04.084
pii:
doi:
Substances chimiques
AGER protein, human
0
Receptor for Advanced Glycation End Products
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-37Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.