Outbreak of aseptic meningitis caused by echovirus 30 in Kushiro, Japan in 2017.
Adolescent
Antibodies, Neutralizing
/ blood
Cerebrospinal Fluid
/ cytology
Child
Child, Preschool
Disease Outbreaks
Echovirus Infections
/ epidemiology
Enterovirus B, Human
/ classification
Female
Genotype
Hospitals, Pediatric
Humans
Infant
Japan
/ epidemiology
Male
Meningitis, Aseptic
/ epidemiology
Phylogeny
RNA, Viral
/ genetics
Viral Proteins
/ genetics
Aseptic meningitis
Children
Echovirus 30
Enterovirus
Outbreak
Journal
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
ISSN: 1873-5967
Titre abrégé: J Clin Virol
Pays: Netherlands
ID NLM: 9815671
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
14
01
2019
revised:
23
04
2019
accepted:
05
05
2019
pubmed:
15
5
2019
medline:
19
6
2020
entrez:
15
5
2019
Statut:
ppublish
Résumé
Echovirus 30 (E30) is one of the most common causative agents for aseptic meningitis. In the autumn of 2017, there was an outbreak caused by E30 in Kushiro, Hokkaido, Japan. The aim of this study was to characterize this outbreak. Fifty-nine patients were admitted to the Department of Pediatrics, Kushiro Red Cross Hospital (KRCH) with clinical diagnosis of aseptic meningitis. Among those, 36 patients were finally diagnosed as E30-associated aseptic meningitis by the detection of viral RNA using reverse transcription-polymerase chain reaction (RT-PCR) and/or the evidence of more than four-fold rise in neutralizing antibody (NA) titers in the convalescent phase relative to those in the acute phase. We investigated these 36 confirmed cases. The median age was 6 years (range: 6 months-14 years). The positive signs and symptoms were as follows: fever (100%), headache (94%), vomiting (92%), jolt accentuation (77%), neck stiffness (74%), Kernig sign (29%), and abdominal pain (28%). The median cerebrospinal fluid (CSF) white cell count, neutrophil count, and lymphocyte count were 222/μL (range: 3-1434/μL), 144/μL (range: 1-1269/μL), and 85/μL (range: 2-354/μL), respectively. Although the detected viral genes demonstrated same cluster, they were different from E30 strains observed in Japan between 2010 and 2014. We mainly showed clinical and virological features of the E30-associated aseptic meningitis outbreak that occurred in Kushiro. To prevent further spread of E30 infection, continuous surveillance of enterovirus (EV) circulation and standard precautions are considered essential.
Sections du résumé
BACKGROUND
Echovirus 30 (E30) is one of the most common causative agents for aseptic meningitis.
OBJECTIVES
In the autumn of 2017, there was an outbreak caused by E30 in Kushiro, Hokkaido, Japan. The aim of this study was to characterize this outbreak.
STUDY DESIGN
Fifty-nine patients were admitted to the Department of Pediatrics, Kushiro Red Cross Hospital (KRCH) with clinical diagnosis of aseptic meningitis. Among those, 36 patients were finally diagnosed as E30-associated aseptic meningitis by the detection of viral RNA using reverse transcription-polymerase chain reaction (RT-PCR) and/or the evidence of more than four-fold rise in neutralizing antibody (NA) titers in the convalescent phase relative to those in the acute phase. We investigated these 36 confirmed cases.
RESULTS
The median age was 6 years (range: 6 months-14 years). The positive signs and symptoms were as follows: fever (100%), headache (94%), vomiting (92%), jolt accentuation (77%), neck stiffness (74%), Kernig sign (29%), and abdominal pain (28%). The median cerebrospinal fluid (CSF) white cell count, neutrophil count, and lymphocyte count were 222/μL (range: 3-1434/μL), 144/μL (range: 1-1269/μL), and 85/μL (range: 2-354/μL), respectively. Although the detected viral genes demonstrated same cluster, they were different from E30 strains observed in Japan between 2010 and 2014.
CONCLUSION
We mainly showed clinical and virological features of the E30-associated aseptic meningitis outbreak that occurred in Kushiro. To prevent further spread of E30 infection, continuous surveillance of enterovirus (EV) circulation and standard precautions are considered essential.
Identifiants
pubmed: 31082730
pii: S1386-6532(19)30098-8
doi: 10.1016/j.jcv.2019.05.001
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
RNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-38Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.