Synthesis and preclinical evaluation of the CRTH2 antagonist [
Animals
Carbolines
/ chemical synthesis
Carbon Radioisotopes
Cell Size
Chemistry Techniques, Synthetic
Humans
Insulin-Secreting Cells
/ cytology
Male
Positron Emission Tomography Computed Tomography
/ methods
Radioactive Tracers
Radiochemistry
Rats
Receptors, Immunologic
/ antagonists & inhibitors
Receptors, Prostaglandin
/ antagonists & inhibitors
Swine
Tissue Distribution
CRTH2
Carbon-11
Diabetes
GPR44
MK-7246
PET
Journal
Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
09
12
2018
revised:
08
03
2019
accepted:
05
04
2019
pubmed:
15
5
2019
medline:
6
5
2020
entrez:
15
5
2019
Statut:
ppublish
Résumé
MK-7246 is a potent and selective antagonist for chemoattractant receptor-homologous molecule expressed on T The precursor N-desmethyl-O-methyl MK-7246 was synthesized in seven steps and subjected to methylation with [ [ Initial preclinical in vitro and in vivo evaluations of [
Identifiants
pubmed: 31082767
pii: S0969-8051(18)30355-X
doi: 10.1016/j.nucmedbio.2019.04.002
pii:
doi:
Substances chimiques
((7R)-7-(((4-fluorophenyl)sulfonyl)(methyl)amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)acetic acid
0
Carbolines
0
Carbon Radioisotopes
0
Carbon-11
0
Radioactive Tracers
0
Receptors, Immunologic
0
Receptors, Prostaglandin
0
prostaglandin D2 receptor
XZF106QU24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.