Mats Larhed

Affiliations

Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.

Publications (24)

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model.

Pharmaceutics

Avec: Fanny Lundmark , Ayman Abouzayed , Bogdan Mitran , Sara S Rinne , Zohreh Varasteh , Mats Larhed , Vladimir Tolmachev , Ulrika Rosenström , Anna Orlova

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.

ACS medicinal chemistry letters

Avec: Anastasia Mpakali , Emmanuel Saridakis , Petros Giastas , Zachary Maben , Lawrence J Stern , Mats Larhed , Mathias Hallberg , Efstratios Stratikos

Two-Chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles.

The Journal of organic chemistry

Avec: Jens Lindman , Anubha Yadav , Johan Gising , Mats Larhed

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds.

International journal of molecular sciences

Avec: Johan Gising , Saman Honarnejad , Maaike Bras , Gemma L Baillie , Stuart P McElroy , Philip S Jones , Angus Morrison , Julia Beveridge , Mathias Hallberg , Mats Larhed

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors.

ChemistryOpen

Avec: Karin Engen , Sudarsana Reddy Vanga , Thomas Lundbäck , Faith Agalo , Vivek Konda , Annika Jenmalm Jensen , Johan Åqvist , Hugo Gutiérrez-de-Terán , Mathias Hallberg , Mats Larhed , Ulrika Rosenström

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer.

Cancers

Avec: Bogdan Mitran , Zohreh Varasteh , Ayman Abouzayed , Sara S Rinne , Emmi Puuvuori , Maria De Rosa , Mats Larhed , Vladimir Tolmachev , Anna Orlova , Ulrika Rosenström

A Series of Analogues to the AT

ChemistryOpen

Avec: Rebecka Isaksson , Jens Lindman , Johan Wannberg , Jessica Sallander , Maria Backlund , Dhaniel Baraldi , Robert Widdop , Mathias Hallberg , Johan Åqvist , Hugo Gutierrez de Teran , Johan Gising , Mats Larhed

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures.

Current issues in molecular biology

Avec: Frida Stam , Sara Florén Lind , Anja Schroff , Sofia Zelleroth , Erik Nylander , Johan Gising , Alfhild Grönbladh , Mats Larhed , Mathias Hallberg

Synthesis and preclinical evaluation of the CRTH2 antagonist [

Nuclear medicine and biology

Avec: Jonas Eriksson , Tamal Roy , Supaporn Sawadjoon , Kim Bachmann , Christian Sköld , Mats Larhed , Jan Weis , Ram Kumar Selvaraju , Olle Korsgren , Olof Eriksson , Luke R Odell

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.

Bioorganic & medicinal chemistry

Avec: Johan Wannberg , Johan Gising , Jens Lindman , Jessica Salander , Hugo Gutiérrez-de-Terán , Hanin Ablahad , Selin Hamid , Alfhild Grönbladh , Iresha Spizzo , Tracey A Gaspari , Robert E Widdop , Anders Hallberg , Maria Backlund , Anna Leśniak , Mathias Hallberg , Mats Larhed

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).

RSC medicinal chemistry

Avec: Nicholas Barlow , Sudarsana Reddy Vanga , Jonas Sävmarker , Anja Sandström , Peta Burns , Anders Hallberg , Johan Åqvist , Hugo Gutiérrez-de-Terán , Mathias Hallberg , Mats Larhed , Siew Yeen Chai , Philip E Thompson

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands.

Bioorganic & medicinal chemistry

Avec: Tamal Roy , Nadia N Petersen , Greeshma Gopalan , Johan Gising , Mathias Hallberg , Mats Larhed

N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands.

European journal of medicinal chemistry

Avec: Johan Wannberg , Johan Gising , Martin Henriksson , Duc Duy Vo , Jonas Sävmarker , Jessica Sallander , Hugo Gutiérrez-de-Terán , Johanna Larsson , Selin Hamid , Hanin Ablahad , Iresha Spizzo , Tracey A Gaspari , Robert E Widdop , Alfhild Grönbladh , Nadia N Petersen , Maria Backlund , Mathias Hallberg , Mats Larhed

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist

International journal of cancer

Avec: Bogdan Mitran , Sara S Rinne , Mark W Konijnenberg , Theodosia Maina , Berthold A Nock , Mohamed Altai , Anzhelika Vorobyeva , Mats Larhed , Vladimir Tolmachev , Marion de Jong , Ulrika Rosenström , Anna Orlova

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase.

Frontiers in pharmacology

Avec: Mathias Hallberg , Mats Larhed

Synthesis and

ACS infectious diseases

Avec: Lu Lu , Linda Åkerbladh , Shabbir Ahmad , Vivek Konda , Sha Cao , Anthony Vocat , Louis Maes , Stewart T Cole , Diarmaid Hughes , Mats Larhed , Peter Brandt , Anders Karlén , Sherry L Mowbray

The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat.

Hormones and behavior

Avec: Sofia Zelleroth , Frida Stam , Erik Nylander , Ellinor Kjellgren , Johan Gising , Mats Larhed , Alfhild Grönbladh , Mathias Hallberg

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines-Synthesis and Evaluation.

International journal of molecular sciences

Avec: Karin Engen , Thomas Lundbäck , Anubha Yadav , Sharathna Puthiyaparambath , Ulrika Rosenström , Johan Gising , Annika Jenmalm-Jensen , Mathias Hallberg , Mats Larhed

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: P Nordeman , Z P Jayendra , E Briard , S C Li , M Larhed , G Antoni , S Estrada , R K Selvaraju , O Åberg , M R Jensen , P Stålberg , B Skogseid , A Monazzam

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer.

Pharmaceutics

Avec: Ayman Abouzayed , Cheng-Bin Yim , Bogdan Mitran , Sara S Rinne , Vladimir Tolmachev , Mats Larhed , Ulrika Rosenström , Anna Orlova

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages.

European journal of pharmacology

Avec: Rebecka Isaksson , Anna Casselbrant , Erik Elebring , Mathias Hallberg , Mats Larhed , Lars Fändriks

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction.

The Journal of organic chemistry

Avec: Ahmed Adeyemi , Luke R Odell , Mats Larhed

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds.

Bioorganic & medicinal chemistry

Avec: Greeshma Gopalan , Carlos Palo-Nieto , Nadia N Petersen , Mathias Hallberg , Mats Larhed

Diastereoselective Synthesis of

ACS omega

Avec: Jens Lindman , Greeshma Gopalan , Carlos Palo-Nieto , Peter Brandt , Johan Gising , Mats Larhed

Réseau de co-auteurs

Mathias Hallberg 14 collaborations

Johan Gising 10 collaborations

Ulrika Rosenström 6 collaborations

Bogdan Mitran 4 collaborations

Sara S Rinne 4 collaborations

Vladimir Tolmachev 4 collaborations

Anna Orlova 4 collaborations

Jens Lindman 4 collaborations

Hugo Gutiérrez-de-Terán 4 collaborations

Alfhild Grönbladh 4 collaborations

Ayman Abouzayed 3 collaborations

Johan Åqvist 3 collaborations

Johan Wannberg 3 collaborations

Maria Backlund 3 collaborations

Nadia N Petersen 3 collaborations

Greeshma Gopalan 3 collaborations

Zohreh Varasteh 2 collaborations

Anubha Yadav 2 collaborations

Karin Engen 2 collaborations

Sudarsana Reddy Vanga 2 collaborations

Thomas Lundbäck 2 collaborations

Vivek Konda 2 collaborations

Rebecka Isaksson 2 collaborations

Jessica Sallander 2 collaborations

Frida Stam 2 collaborations

Sofia Zelleroth 2 collaborations

Erik Nylander 2 collaborations

Tamal Roy 2 collaborations

Luke R Odell 2 collaborations

Hanin Ablahad 2 collaborations

Selin Hamid 2 collaborations

Iresha Spizzo 2 collaborations

Tracey A Gaspari 2 collaborations

Robert E Widdop 2 collaborations

Anders Hallberg 2 collaborations

Jonas Sävmarker 2 collaborations

Peter Brandt 2 collaborations

Carlos Palo-Nieto 2 collaborations

Fanny Lundmark 1 collaboration

Anastasia Mpakali 1 collaboration

Emmanuel Saridakis 1 collaboration

Petros Giastas 1 collaboration

Zachary Maben 1 collaboration

Lawrence J Stern 1 collaboration

Efstratios Stratikos 1 collaboration

Saman Honarnejad 1 collaboration

Maaike Bras 1 collaboration

Gemma L Baillie 1 collaboration

Stuart P McElroy 1 collaboration

Philip S Jones 1 collaboration

Angus Morrison 1 collaboration

Julia Beveridge 1 collaboration

Faith Agalo 1 collaboration

Annika Jenmalm Jensen 1 collaboration

Emmi Puuvuori 1 collaboration

Maria De Rosa 1 collaboration

Dhaniel Baraldi 1 collaboration

Robert Widdop 1 collaboration

Hugo Gutierrez de Teran 1 collaboration

Sara Florén Lind 1 collaboration

Anja Schroff 1 collaboration

Jonas Eriksson 1 collaboration

Supaporn Sawadjoon 1 collaboration

Kim Bachmann 1 collaboration

Christian Sköld 1 collaboration

Jan Weis 1 collaboration

Ram Kumar Selvaraju 1 collaboration

Olle Korsgren 1 collaboration

Olof Eriksson 1 collaboration

Jessica Salander 1 collaboration

Anna Leśniak 1 collaboration

Nicholas Barlow 1 collaboration

Anja Sandström 1 collaboration

Peta Burns 1 collaboration

Siew Yeen Chai 1 collaboration

Philip E Thompson 1 collaboration

Martin Henriksson 1 collaboration

Duc Duy Vo 1 collaboration

Johanna Larsson 1 collaboration

Mark W Konijnenberg 1 collaboration

Theodosia Maina 1 collaboration

Berthold A Nock 1 collaboration

Mohamed Altai 1 collaboration

Anzhelika Vorobyeva 1 collaboration

Marion de Jong 1 collaboration

Lu Lu 1 collaboration

Linda Åkerbladh 1 collaboration

Shabbir Ahmad 1 collaboration

Sha Cao 1 collaboration

Anthony Vocat 1 collaboration

Louis Maes 1 collaboration

Stewart T Cole 1 collaboration

Diarmaid Hughes 1 collaboration

Anders Karlén 1 collaboration

Sherry L Mowbray 1 collaboration

Ellinor Kjellgren 1 collaboration

Sharathna Puthiyaparambath 1 collaboration

Annika Jenmalm-Jensen 1 collaboration

P Nordeman 1 collaboration

Z P Jayendra 1 collaboration

E Briard 1 collaboration

S C Li 1 collaboration

M Larhed 1 collaboration

G Antoni 1 collaboration

S Estrada 1 collaboration

R K Selvaraju 1 collaboration

O Åberg 1 collaboration

M R Jensen 1 collaboration

P Stålberg 1 collaboration

B Skogseid 1 collaboration

A Monazzam 1 collaboration

Cheng-Bin Yim 1 collaboration

Anna Casselbrant 1 collaboration

Erik Elebring 1 collaboration

Lars Fändriks 1 collaboration

Ahmed Adeyemi 1 collaboration