Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages.

Animals Drug Discovery Ligands Lipopolysaccharides / immunology Macrophages / drug effects Mice Nitric Oxide / analysis Nitric Oxide Synthase Type II / metabolism RAW 264.7 Cells Receptor, Angiotensin, Type 2 / agonists Renin-Angiotensin System / drug effects Sulfonamides / pharmacology Thiophenes / pharmacology
Agonist Antagonist Bioassay Functional activity Inducible nitric oxide synthase Renin-angiotensin-aldosterone system

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
05 Feb 2020
Historique:
received: 11 10 2019
revised: 04 12 2019
accepted: 09 12 2019
pubmed: 15 12 2019
medline: 21 10 2020
entrez: 15 12 2019
Statut: ppublish

Résumé

The angiotensin II type 2 receptor (AT

Identifiants

DOI: 10.1016/j.ejphar.2019.172855 PMID: 31837306
pubmed: 31837306
pii: S0014-2999(19)30807-6
doi: 10.1016/j.ejphar.2019.172855
pii:
doi:

Substances chimiques

Ligands 0
Lipopolysaccharides 0
N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide 0
Receptor, Angiotensin, Type 2 0
Sulfonamides 0
Thiophenes 0
Nitric Oxide 31C4KY9ESH
Nitric Oxide Synthase Type II EC 1.14.13.39
Nos2 protein, mouse EC 1.14.13.39

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

172855

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Rebecka Isaksson (R)

Preparative Medicinal Chemistry, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23, Uppsala, Sweden.

Anna Casselbrant (A)

Department of Gastrosurgical Research and Education, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden. Electronic address: anna.casselbrant@gastro.gu.se.

Erik Elebring (E)

Department of Gastrosurgical Research and Education, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.

Mathias Hallberg (M)

The Beijer Laboratory, Department of Pharmaceutical Biosciences, Uppsala University, BMC Box 591, SE-751 24, Uppsala, Sweden.

Mats Larhed (M)

The Beijer Laboratory, Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23, Uppsala, Sweden.

Lars Fändriks (L)

Department of Gastrosurgical Research and Education, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteurs aux angiotensines › Récepteur de type 2 à l'angiotensine-II › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Direct stimulation of angiotensin II type 2...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Thiophènes › Direct stimulation of angiotensin II type 2...