2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands.

Benzimidazoles / pharmacology Humans Imidazoles Ligands Receptor, Angiotensin, Type 2 / agonists Sulfonamides Thiazoles Thiophenes
AT(2)R ligands AT(2)R/AT(1)R selectivity Angiotensin II type 2 receptor Benzimidazole sulfonyl carbamates Liver microsomes

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 07 2022
Historique:
received: 04 03 2022
revised: 25 04 2022
accepted: 03 05 2022
pubmed: 17 5 2022
medline: 3 6 2022
entrez: 16 5 2022
Statut: ppublish

Résumé

Ligands comprising a benzimidazole rather than the imidazole ring that is common in AT

Identifiants

DOI: 10.1016/j.bmc.2022.116804 PMID: 35576659
pubmed: 35576659
pii: S0968-0896(22)00196-1
doi: 10.1016/j.bmc.2022.116804
pii:
doi:

Substances chimiques

Benzimidazoles 0
Imidazoles 0
Ligands 0
Receptor, Angiotensin, Type 2 0
Sulfonamides 0
Thiazoles 0
Thiophenes 0
compound 21 RC2V4W0EYC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116804

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Tamal Roy (T)

The Beijer Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23 Uppsala, Sweden.

Nadia N Petersen (NN)

The Beijer Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23 Uppsala, Sweden.

Greeshma Gopalan (G)

The Beijer Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23 Uppsala, Sweden.

Johan Gising (J)

The Beijer Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23 Uppsala, Sweden.

Mathias Hallberg (M)

The Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, BMC, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden.

Mats Larhed (M)

The Beijer Laboratory, Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, BMC Box 574, SE-751 23 Uppsala, Sweden. Electronic address: mats.larhed@ilk.uu.se.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteurs aux angiotensines › Récepteur de type 2 à l'angiotensine-II › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › 2-Alkyl substituted benzimidazoles as a new...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Thiophènes › 2-Alkyl substituted benzimidazoles as a new...