High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Animals
Diet, High-Fat
/ adverse effects
Dietary Fats
/ adverse effects
Endoplasmic Reticulum Stress
Glucose
/ metabolism
Glucose Intolerance
/ metabolism
Hepatocytes
/ drug effects
Insulin
/ metabolism
Insulin Resistance
/ physiology
Interleukin-6
/ pharmacology
Liver
/ drug effects
Male
Mice
Mice, Inbred C57BL
Obesity
/ chemically induced
Phenylbutyrates
/ pharmacology
Signal Transduction
/ drug effects
Tunicamycin
/ pharmacology
fatty acids
glucose
hepatic glucose output
liver
steatohepatitis
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
13
01
2019
revised:
23
04
2019
pubmed:
16
5
2019
medline:
14
7
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
The relationship between liver interleukin-6 (IL-6) resistance following high-fat diet (HFD)-induced obesity and glucose intolerance is unclear. The purpose of this study was to assess the temporal development of hepatic IL-6 resistance and the role of endoplasmic reticulum (ER) stress in this process. We hypothesized that HFD would rapidly induce hepatic IL-6 resistance through a mechanism involving ER stress. Male C57BL/6N mice consumed chow or a HFD (60%) derived from lard (saturated) or olive oil (monounsaturated) for 4 days or 7 weeks before being injected intraperitoneally with IL-6 (6 ng·kg
Identifiants
pubmed: 31085628
pii: S0022-2275(20)31056-7
doi: 10.1194/jlr.M092510
pmc: PMC6602138
doi:
Substances chimiques
Dietary Fats
0
Insulin
0
Interleukin-6
0
Phenylbutyrates
0
Tunicamycin
11089-65-9
4-phenylbutyric acid
7WY7YBI87E
Glucose
IY9XDZ35W2
lard
SI6O3IW77Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1236-1249Subventions
Organisme : BLRD VA
ID : I01 BX003271
Pays : United States
Informations de copyright
Copyright © 2019 Townsend et al.
Références
Life Sci. 2000 Jun 8;67(3):291-300
pubmed: 10983873
J Clin Endocrinol Metab. 2000 Sep;85(9):3338-42
pubmed: 10999830
Am J Physiol Endocrinol Metab. 2001 May;280(5):E745-51
pubmed: 11287357
Nat Med. 2002 Jan;8(1):75-9
pubmed: 11786910
Annu Rev Med. 2002;53:319-36
pubmed: 11818477
Diabetes. 2002 Dec;51(12):3391-9
pubmed: 12453891
J Biol Chem. 2003 Apr 18;278(16):13740-6
pubmed: 12560330
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3077-82
pubmed: 12629214
Biochem J. 2003 Aug 15;374(Pt 1):1-20
pubmed: 12773095
Nat Med. 2004 Feb;10(2):168-74
pubmed: 14716305
J Biol Chem. 2004 Jul 30;279(31):32345-53
pubmed: 15166226
Hepatology. 2004 Jul;40(1):185-94
pubmed: 15239102
Science. 2004 Oct 15;306(5695):457-61
pubmed: 15486293
J Clin Invest. 2005 May;115(5):1111-9
pubmed: 15864338
J Clin Invest. 2005 May;115(5):1343-51
pubmed: 15864352
Endocrinology. 2006 Feb;147(2):943-51
pubmed: 16269465
Science. 2006 Aug 25;313(5790):1137-40
pubmed: 16931765
J Biol Chem. 2006 Dec 1;281(48):36683-90
pubmed: 17028185
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
J Clin Invest. 2007 Apr;117(4):841-9
pubmed: 17404609
Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G619-26
pubmed: 18174272
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8
pubmed: 18719127
Cell Metab. 2009 Jan 7;9(1):35-51
pubmed: 19117545
Mol Endocrinol. 2009 Jun;23(6):827-37
pubmed: 19264844
Expert Rev Gastroenterol Hepatol. 2009 Aug;3(4):445-51
pubmed: 19673631
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1903-7
pubmed: 2000394
Diabetes. 2010 Jun;59(6):1302-11
pubmed: 20185816
J Hepatol. 2010 Apr;52(4):586-93
pubmed: 20206402
Cell. 2010 Mar 19;140(6):900-17
pubmed: 20303879
Diabetologia. 2010 Nov;53(11):2431-41
pubmed: 20697689
Cell Metab. 2010 Sep 8;12(3):237-49
pubmed: 20816090
Diabetes. 2011 Sep;60(9):2206-15
pubmed: 21715553
Cell Metab. 2011 Jul 6;14(1):9-19
pubmed: 21723500
Diabetes. 2011 Oct;60(10):2474-83
pubmed: 21911747
Nat Med. 2011 Oct 30;17(11):1481-9
pubmed: 22037645
Diabetes. 2012 Jan;61(1):61-73
pubmed: 22124464
Metabolism. 2013 Jan;62(1):152-62
pubmed: 22981137
Hepatology. 2013 Jun;57(6):2213-23
pubmed: 23359250
Mol Cell Endocrinol. 2014 Aug 5;393(1-2):143-51
pubmed: 24976178
Nat Commun. 2015 Jan 12;6:6047
pubmed: 25581158
Med Sci Sports Exerc. 2015 Oct;47(10):2034-42
pubmed: 25785928
Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R594-602
pubmed: 26180183
Nat Cell Biol. 2015 Sep;17(9):1099-111
pubmed: 26280538
Cell Metab. 2015 Oct 6;22(4):669-81
pubmed: 26344103
Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R315-24
pubmed: 27101294
Sci Rep. 2016 Jun 07;6:27541
pubmed: 27273128
Shock. 2017 Apr;47(4):506-513
pubmed: 27755507
Cell Rep. 2017 Apr 11;19(2):267-280
pubmed: 28402851
Cell Metab. 2017 Jul 5;26(1):157-170.e7
pubmed: 28683283
Nat Rev Endocrinol. 2017 Oct;13(10):572-587
pubmed: 28731034
Cell Metab. 2017 Aug 1;26(2):407-418.e3
pubmed: 28768178
J Biol Chem. 2017 Oct 6;292(40):16653-16664
pubmed: 28808062
Cell Metab. 2017 Oct 3;26(4):660-671.e3
pubmed: 28844881
Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E66-E77
pubmed: 28978546
Psychoneuroendocrinology. 2018 Feb;88:121-128
pubmed: 29241148
Cell Metab. 2018 Jun 05;27(6):1201-1211.e3
pubmed: 29731416
J Lipid Res. 2018 Aug;59(8):1482-1500
pubmed: 29866659
Int J Mol Sci. 2018 Aug 04;19(8):null
pubmed: 30081561
J Physiol. 2018 Sep;596(18):4375-4391
pubmed: 30109697
JCI Insight. 2018 Aug 23;3(16):null
pubmed: 30135314
Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G166-G178
pubmed: 30383412
FASEB J. 2019 Apr;33(4):4824-4835
pubmed: 30615494