Hydroxychloroquine-induced podocytopathy mimicking Fabry disease.
pathology
proteinurea
renal system
unwanted effects/adverse reactions
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
13 May 2019
13 May 2019
Historique:
entrez:
16
5
2019
pubmed:
16
5
2019
medline:
25
12
2019
Statut:
epublish
Résumé
Hydroxychloroquine (HCQ) is largely prescribed as an immunomodulator to prevent systemic diseases flares in patients with systemic lupus erythematous, rheumatoid arthritis, Sjogren's disease. Among reported side effects, HCQ can accumulate in lysosomes and induced phospholipidosis. Here, we report an HCQ-induced podocytopathy mimicking Fabry disease (FD). They share the same histological lesions: cytoplasmic vacuolisation of the podocytes and zebra bodies on light and electronic microscopy. FD has been ruled out by measuring enzymatic activity and genetic test. The persistence of proteinuria after immunological remission of a systemic disease treated with HCQ could suggest this HCQ-induced podocytopathy.
Identifiants
pubmed: 31088818
pii: 12/5/e228876
doi: 10.1136/bcr-2018-228876
pmc: PMC6536225
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Hydroxychloroquine
4QWG6N8QKH
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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