DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.
Animals
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Azacitidine
/ administration & dosage
Cystadenocarcinoma, Serous
/ drug therapy
Disease Models, Animal
Eflornithine
/ administration & dosage
Female
Immunity, Innate
/ drug effects
Macrophages
/ drug effects
Mice
Mice, Inbred C57BL
Ovarian Neoplasms
/ drug therapy
Polyamines
/ metabolism
Tumor Cells, Cultured
Tumor Microenvironment
/ drug effects
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
20
12
2018
revised:
25
03
2019
accepted:
07
05
2019
pubmed:
16
5
2019
medline:
9
4
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFNγ
Identifiants
pubmed: 31088836
pii: 0008-5472.CAN-18-4018
doi: 10.1158/0008-5472.CAN-18-4018
pmc: PMC6606334
mid: NIHMS1529293
doi:
Substances chimiques
Polyamines
0
Azacitidine
M801H13NRU
Eflornithine
ZQN1G5V6SR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3445-3454Subventions
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204345
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008752
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM135457
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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