miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8

Adoptive Transfer / methods Animals CD8-Positive T-Lymphocytes / immunology Cell Differentiation / genetics Cellular Senescence / genetics Epigenesis, Genetic / immunology Female Gene Expression Regulation, Neoplastic Humans Melanoma, Experimental / genetics Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs / metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases / genetics Polycomb Repressive Complex 2 / immunology Skin Neoplasms / genetics Transcription Factors / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
14 05 2019
Historique:
received: 29 05 2018
accepted: 02 04 2019
entrez: 16 5 2019
pubmed: 16 5 2019
medline: 2 7 2019
Statut: epublish

Résumé

T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8

Identifiants

DOI: 10.1038/s41467-019-09882-8 PMID: 31089138 PMC: PMC6517388
pubmed: 31089138
doi: 10.1038/s41467-019-09882-8
pii: 10.1038/s41467-019-09882-8
pmc: PMC6517388
doi:

Substances chimiques

MicroRNAs 0
Mirn155 microRNA, mouse 0
Phf19 protein, mouse 0
Transcription Factors 0
Polycomb Repressive Complex 2 EC 2.1.1.43
Inpp5d protein, mouse EC 3.1.3.86
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases EC 3.1.3.86

Types de publication

Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2157

Subventions

Organisme : Intramural NIH HHS
ID : ZIA BC011480
Pays : United States

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Auteurs

Yun Ji (Y)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. yji365@gmail.com.
Cellular Biomedicine Group (CBMG), Gaithersburg, MD, 20877, USA. yji365@gmail.com.
ORCID: 0000-0001-6340-7009

Jessica Fioravanti (J)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0001-6263-4306

Wei Zhu (W)

Department of Bioinformatics, Inova Translational Medicine Institute, Fairfax, VA, 22031, USA.

Hongjun Wang (H)

Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Tuoqi Wu (T)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Jinhui Hu (J)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Neal E Lacey (NE)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0002-3633-5924

Sanjivan Gautam (S)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

John B Le Gall (JB)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Xia Yang (X)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

James D Hocker (JD)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Thelma M Escobar (TM)

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Shan He (S)

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, 19140, USA.

Stefania Dell'Orso (S)

Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0002-1306-2820

Nga V Hawk (NV)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Veena Kapoor (V)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

William G Telford (WG)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Luciano Di Croce (L)

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain.
ICREA, Pg. Lluis Companys 23, 08010, Barcelona, Spain.
ORCID: 0000-0003-3488-6228

Stefan A Muljo (SA)

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Yi Zhang (Y)

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, 19140, USA.

Vittorio Sartorelli (V)

Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Luca Gattinoni (L)

Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. gattinol@mail.nih.gov.
ORCID: 0000-0003-2239-3282

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Mélanome expérimental › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphoinositide phosphatases › Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-2 › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › miR-155 harnesses Phf19 to potentiate cancer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › miR-155 harnesses Phf19 to potentiate cancer...