Quantification of 3D Brain Microangioarchitectures in an Animal Model of Krabbe Disease.
angioarchitecture
angiogenesis
brain cortex
image analysis
lysosomal storage diseases
neurodegeneration
sphingolipidosis
vessel quantification
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 May 2019
14 May 2019
Historique:
received:
18
04
2019
revised:
08
05
2019
accepted:
11
05
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
27
8
2019
Statut:
epublish
Résumé
We performed a three-dimensional (3D) analysis of the microvascular network of the cerebral cortex of twitcher mice (an authentic model of Krabbe disease) using a restricted set of indexes that are able to describe the arrangement of the microvascular tree in CD31-stained sections. We obtained a near-linear graphical "fingerprint" of the microangioarchitecture of wild-type and twitcher animals that describes the amounts, spatial dispersion, and spatial relationships of adjacent classes of caliber-filtered microvessels. We observed significant alterations of the microangioarchitecture of the cerebral cortex of twitcher mice, whereas no alterations occur in renal microvessels, which is keeping with the observation that kidney is an organ that is not affected by the disease. This approach may represent an important starting point for the study of the microvascular changes that occur in the central nervous system (CNS) under different physiopathological conditions.
Identifiants
pubmed: 31091708
pii: ijms20102384
doi: 10.3390/ijms20102384
pmc: PMC6567268
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 14395
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 18493
Organisme : Fondazione Cariplo
ID : 2016-0570
Organisme : Regione Lombardia/CNR
ID : CUP B42F16000440005
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