Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus.


Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
07 2019
Historique:
pubmed: 17 5 2019
medline: 29 2 2020
entrez: 17 5 2019
Statut: ppublish

Résumé

Objective- Albuminuria is an important risk factor for cardiovascular disease in diabetes mellitus. We determined whether albuminuria associates with alterations in the proteome of HDL (high-density lipoprotein) of subjects with type 1 diabetes mellitus and whether those alterations associated with coronary artery calcification. Approach and Results- In a cross-sectional study of 191 subjects enrolled in the DCCT (Diabetes Control and Complications Trial)/EDIC study (Epidemiology of Diabetes Interventions and Complications), we used isotope dilution tandem mass spectrometry to quantify 46 proteins in HDL. Stringent statistical analysis demonstrated that 8 proteins associated with albuminuria. Two of those proteins, AMBP (α1-microglobulin/bikunin precursor) and PTGDS (prostaglandin-H2 D-isomerase), strongly and positively associated with the albumin excretion rate ( P<10

Identifiants

pubmed: 31092010
doi: 10.1161/ATVBAHA.119.312556
pmc: PMC6594860
mid: NIHMS1528623
doi:

Substances chimiques

Lipoproteins, HDL 0
Aryldialkylphosphatase EC 3.1.8.1
PON1 protein, human EC 3.1.8.1
PON3 protein, human EC 3.1.8.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1483-1491

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL112625
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL128203
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK108209
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL108897
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL091055
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL092969
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States

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Auteurs

Baohai Shao (B)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

Leila R Zelnick (LR)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

Jake Wimberger (J)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

Jonathan Himmelfarb (J)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

John Brunzell (J)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

W Sean Davidson (WS)

Department of Pathology and Laboratory Medicine, University of Cincinnati, OH (W.S.D.).

Janet K Snell-Bergeon (JK)

Barbara Davis Center for Diabetes, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora (J.K.S.-B.).

Karin E Bornfeldt (KE)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

Ian H de Boer (IH)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

Jay W Heinecke (JW)

From the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).

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Classifications MeSH