CD4
Adjuvants, Immunologic
/ administration & dosage
Animals
CD4-Positive T-Lymphocytes
/ immunology
Disease Models, Animal
Immunization
/ adverse effects
Lung
/ pathology
Lung Diseases
/ pathology
Mice
Mice, Inbred BALB C
Respiratory Syncytial Virus Infections
/ pathology
Respiratory Syncytial Virus Vaccines
/ administration & dosage
Vaccines, Subunit
/ administration & dosage
Viral Fusion Proteins
/ immunology
GLA-SE
RSV
RSV F
enhanced RSV disease
suboptimal vaccine
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
25
04
2019
accepted:
08
05
2019
pubmed:
17
5
2019
medline:
2
6
2020
entrez:
17
5
2019
Statut:
epublish
Résumé
Respiratory syncytial virus (RSV) infection of seronegative children previously immunized with formalin-inactivated (FI) RSV has been associated with serious enhanced respiratory disease (ERD). The phenomenon was reproduced in the cotton rat and the mouse, and both preclinical models have been routinely used to evaluate the safety of new RSV vaccine candidates. More recently, we demonstrated that immunizations with suboptimal doses of the RSV fusion (F) antigen, in its post- or prefusion conformation, and in the presence of a Th1-biasing adjuvant, unexpectedly led to ERD in the cotton rat model. To assess if those observations are specific to the cotton rat and to elucidate the mechanism by which vaccination with low antigen doses can drive ERD post-RSV challenge, we evaluated RSV post-F antigen dose de-escalation in BALB/c mice in the presence of a Th1-biasing adjuvant. While decreasing antigen doses, we observed an increase in lung inflammation associated with an upregulation of proinflammatory cytokines. The amplitude of the lung histopathology was comparable to that of FI-RSV-induced ERD, confirming the observations made in the cotton rat. Importantly, depletion of CD4
Identifiants
pubmed: 31092578
pii: JVI.00695-19
doi: 10.1128/JVI.00695-19
pmc: PMC6639276
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
F protein, human respiratory syncytial virus
0
Respiratory Syncytial Virus Vaccines
0
Vaccines, Subunit
0
Viral Fusion Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
J Virol. 2001 Dec;75(24):12421-30
pubmed: 11711632
J Virol. 1992 Dec;66(12):7444-51
pubmed: 1433525
Respiration. 2005 May-Jun;72(3):263-9
pubmed: 15942295
J Immunol Methods. 2007 Oct 31;327(1-2):63-74
pubmed: 17716680
J Immunol. 2007 Oct 15;179(8):5415-24
pubmed: 17911628
J Immunol. 2008 Nov 15;181(10):6692-6
pubmed: 18981084
N Engl J Med. 2009 Feb 5;360(6):588-98
pubmed: 19196675
Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):123-32
pubmed: 19748238
Vaccine. 2011 Nov 8;29(48):9081-92
pubmed: 21963872
Expert Rev Vaccines. 2011 Oct;10(10):1415-33
pubmed: 21988307
J Infect Dis. 2012 Jul 1;206(1):56-62
pubmed: 22529314
Vaccine. 2013 Apr 18;31 Suppl 2:B209-15
pubmed: 23598484
Curr Opin Virol. 2013 Jun;3(3):332-42
pubmed: 23727193
J Virol. 2013 Oct;87(20):11107-20
pubmed: 23926341
Science. 2013 Nov 1;342(6158):592-8
pubmed: 24179220
Curr Top Microbiol Immunol. 2013;372:347-58
pubmed: 24362698
PLoS One. 2013 Dec 23;8(12):e83075
pubmed: 24376637
J Clin Microbiol. 1988 Aug;26(8):1595-7
pubmed: 2459154
J Virol. 1989 Jul;63(7):2941-50
pubmed: 2470922
Immunol Res. 2014 Aug;59(1-3):109-17
pubmed: 24838148
PLoS Pathog. 2015 Mar 13;11(3):e1004757
pubmed: 25769044
Clin Vaccine Immunol. 2015 Dec 16;23(3):189-95
pubmed: 26677198
J Virol. 2017 Mar 29;91(8):
pubmed: 28148790
J Virol. 2017 Apr 28;91(10):
pubmed: 28275186
Am J Epidemiol. 1969 Apr;89(4):405-21
pubmed: 4305197
Am J Epidemiol. 1969 Apr;89(4):422-34
pubmed: 4305198
Am J Epidemiol. 1969 Apr;89(4):435-48
pubmed: 4305199
Am J Epidemiol. 1969 Apr;89(4):449-63
pubmed: 4305200
Pediatr Res. 1993 Aug;34(2):167-72
pubmed: 8233720
J Virol. 1996 May;70(5):2852-60
pubmed: 8627759
Pediatrics. 1998 Sep;102(3 Pt 1):531-7
pubmed: 9738173
J Immunol. 1999 Feb 15;162(4):2347-52
pubmed: 9973514