Alpha-ketoglutarate mediated hepatoprotection against alcohol induced toxicity:

Alanine Transaminase / analysis Animals Aspartate Aminotransferases / analysis Disease Models, Animal Ethanol / toxicity Ketoglutaric Acids / pharmacology Liver / drug effects Liver Diseases / prevention & control Liver Diseases, Alcoholic / drug therapy Male Radionuclide Imaging Rats Rats, Sprague-Dawley
99mTc-mebrofenin hepatobiliary scintigraphy Alpha-ketoglutarate alcohol functional imaging hepatotoxicity

Journal

Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723

Informations de publication

Date de publication:
Sep 2020
Historique:
pubmed: 17 5 2019
medline: 20 3 2021
entrez: 17 5 2019
Statut: ppublish

Résumé

Alcohol is the most abused psychoactive substance and known hepatotoxicant. Present study elucidates possible therapeutic effect of oral alpha-ketoglutarate (AKG) supplementation against alcohol induced hepatic dysfunction, using biochemical, histopathological and most importantly,

Identifiants

DOI: 10.1080/01480545.2018.1559183 PMID: 31094237
pubmed: 31094237
doi: 10.1080/01480545.2018.1559183
doi:

Substances chimiques

Ketoglutaric Acids 0
Ethanol 3K9958V90M
Aspartate Aminotransferases EC 2.6.1.1
Alanine Transaminase EC 2.6.1.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

546-551

Auteurs

Lalita Mehra (L)

Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Delhi, India.

Harish Rawat (H)

Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Delhi, India.

Abhinav Jaimini (A)

Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Delhi, India.

Amit Tyagi (A)

Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Delhi, India.

Gaurav Mittal (G)

Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Delhi, India.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Alanine transaminase › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Acides cétoglutariques › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Système digestif › Foie › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Troubles dus à des produits chimiques › Troubles dus à l'abus d'alcool › Maladies alcooliques du foie › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Alpha-ketoglutarate mediated hepatoprotection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Alpha-ketoglutarate mediated hepatoprotection...